000 03355cam a2200325 a 4500
003 EG-GiCUC
005 20250223031822.0
008 171009s2016 ua h f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.12.10.M.Sc.2016.Em.S
100 0 _aEman Kamal Mousa Dewidar
245 1 0 _aSynthesis and biological studies of new heterocyclic compounds containing pyrazole, thiazole and/or thiadiazole moieties /
_cEman Kamal Mousa Dewidar ; Supervised Sobhy Mohamed Gomaa
246 1 5 _a{uFE97}{uFEA4}{uFEC0}{uFBFF}{uFEAE} و درا{uئإآ٣}{uئإ٩٤} ا{uئإؤئ}{uئإإ٨}{uئإآ٨}{uئإ٨إ}ط ا{uئإؤئ}{uئإ٩٢}{uئآئئ}{uئإإإ}{uئإؤئ}{uئإإإ}{uئإ٩ئ}{uئإئ٠} {uئإؤئ}{uئإإ٤}{uئإءإ}{uئإؤآ}{uئإ٩٢}{uئإ٨إ}ت {uئإأئ}{uئآئئ}{uئإءإ} {uئإإ٣}{uئإ٩٨}{uئإء٠}{uئإ٨إ}{uئإإ٧}{uئإآ٤}{uئإ٩٤} ا{uئإؤئ}{uئإء٤}{uئإإ٠}{uئإؤ٨}{uئإ٩٤} ا{uئإؤئ}{uئإ٩٨}{uئإئ٠} {uئإ٩٧}{uئإء٤}{uئإ٩٨}{uئإإإ}ى {uئإأآ}{uئإإ٠}{uئإئ٠} {uئإإ٣}{uئإآ٨}{uئإ٩٨}{uئإؤ٨}{uئإ٨إ}ت {uئإء٣}{uئإإ٠}{uئإؤ٨}{uئإ٨إ}ت {uئإ٩١}{uئآئئ}{uئإءإ}ازول: {uئإ٩آ}{uئآئئ}{uئإ٨إ}زول و/ او-{uئإ٩آ}{uئآئئ}{uئإ٨إ}دا{uئآئإ}{uئإ٨إ}زول
260 _aCairo :
_bEman Kamal Mousa Dewidar ,
_c2016
300 _a197 P. :
_bfacsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520 _aThe original work of the submitted thesis consists of two research projects: In the first part: A new series of 7-arylazopyrazolo[5,1-c][1,2,4] triazoles was synthesized via reaction of 3-amino-4-(arylhydrazono)-4,5-dihydropyrazol-5-one with hydrazonoyl halides using triethylamine as a basic catalyst. The structure of all the synthesized compounds was confirmed on the basis of elemental and spectral analyses data. Moreover, the antimicrobial and antitumor activities of these compounds were evaluated and the results obtained indicate the weak efficacy of some of them as antibacterial agents. But, the results of antitumor activity against HepG-2 liver cancer and HCT-116 colon cancer of some derivatives showed good activity in comparison with the reference drugs. In the second part: A novel series of 5-arylazothiazoles was prepared from 2-(-1-morpholino-1-(2-arylhydrazono)propan-2-ylidene)-hydrazinecarbothioamide by different methods. The structures of the newly synthesized compounds were established on the basis of spectroscopic evidences and their synthesis by alternative methods. Moreover, the newly synthesized products were evaluated for their anti-cancer activities and the results show that some derivatives have good to mild utility as antitumor operators. Moreover, the computational studies using MOE 2014.09 software are confirming the results of biological activity
530 _aIssued also as CD
653 4 _aNew heterocyclic compounds containing pyrazole
653 4 _aThiadiazole moieties
653 4 _aThiazole
700 0 _aSobhy Mohamed Gomaa ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aSamia
_eCataloger
942 _2ddc
_cTH
999 _c62821
_d62821