000 03618cam a2200349 a 4500
003 EG-GiCUC
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008 171105s2017 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.23.M.Sc.2017.Mo.P
100 0 _aMohamed Ibrahim Abdelghany
245 1 0 _aProspective dosimetric study comparing tumor volumes and organ-at-risk doses using conventional ct vs. pet/ct fusion planning in cancer esophagus patients who are candidates for neoadjuvant chemo-radiotherapy or definitive radiotherapy /
_cMohamed Ibrahim Abdelghany ; Supervised Mohamed Abdulla Hassan , Manal Mohamed Yehia Elbaradie , Hisham Abdelkader Elhossieny
246 1 5 _aدراسة مستقبلية قياسية للجرعة لمقارنة أحجام الورم وجرعات الإشعاع الواصلة للأعضاء العرضة للخطر بين التخطيط بالأشعة المقطعية العادية والتخطيط بالمسح البوزيتروني المقطعي فى حالات مرضى سرطان المرئ المرشحين لتلقي العلاج الكيماوي الإشعاعي ماقبل الجراحة أو العلاج الإشعاعي الجذري
260 _aCairo :
_bMohamed Ibrahim Abdelghany ,
_c2017
300 _a102 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Oncology (Clinical)
520 _aObjectives To compare tumor volumes & doses to organs at risk in computed tomography (CT)-derived & positron emission tomography/computed tomography (PET/CT) fusion-derived radiotherapy plans, with detection of geographic miss. Also, to evaluate the impact of using PET/CT as a diagnostic tool on the treatment decision. Design Prospective self-controlled dosimetric study of radiotherapy treatment planning for cancer esophagus patients presenting to National Cancer Institute, from December 2015 to December 2016. Methods 20 patients were enrolled in the study. Each patient had PET/CT done. Delineation of tumor target volumes was done on CT images then on PET/CT fused images. Organs at risk were also delineated. Radiotherapy treatment plans were designed for CT-derived & for PET/CT fusion-derived contouring plans. Target volumes in cubic centimeter along with doses to organs at risk were obtained. Geographic miss was detected.The results of PET/CT altered the treatment decision, from curative to palliative, in 25% of the patients, after detection of distant metastases that were missed on CT. There was a highly statistically significant reduction in the tumor volumes based on PET/CT in comparison to CT (p value <0.001). Moreover, PET/CT could detect areas of tumor involvement that were missed on CT 2geographic miss3 in 70% of the patients. In addition, the radiation doses to the heart and lungs were significantly reduced in PET/CT-derived treatment plans compared to CT-derived plans (p value <0.001). The doses to the spinal cord had a marginal significant reduction in PET/CT-derived treatment plans compared to CT-derived plans (p value = 0.08)
530 _aIssued also as CD
653 4 _aCancer esophagus patients
653 4 _aOrgan-at-risk doses
653 4 _aTumor volumes
700 0 _aHisham Abdelkader Elhossieny ,
_eSupervisor
700 0 _aManal Mohamed Yehia Elbaradie ,
_eSupervisor
700 0 _aMohamed Abdulla Hassan ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c63302
_d63302