| 000 | 02547cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031844.0 | ||
| 008 | 171120s2012 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.09.04.Ph.D.2012.Sa.E | ||
| 100 | 0 | _aSana Maher Aghbary | |
| 245 | 1 | 0 |
_aEvaluation of MicroRNA 27b and MicroRNA 137 as biomarkers of activity and malignant transformation in oral Lichen planus patients : _bClinical trial / _cSana Maher Aghbary ; Supervised Soheir Mohamed Gaafar , Olfat Gamil Shaker , Shahira Gamal Elashiry |
| 246 | 1 | 5 | _aكموشرات حيوي للنشاط المرضى والتحول السرطانى في مرضى الحزاز الفموىmicroRNA137و microRNA27b تققيم |
| 260 |
_aCairo : _bSana Maher Aghbary , _c2012 |
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| 300 |
_a98 , (39) P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology | ||
| 520 | _aOral lichen planus (OLP) is a chronic inflammatory muccocutaneous disease with a potential malignant transformation, characterized by cytotoxic T cell against basal epithelial cells. MicroRNAs (miRNAs) are a short non-coding RNA that plays a critical role in gene expression at post-transcriptional levels. Many evidence showed that miRNAs play an important role in regulating immune response and cancer development. The purpose of the present study to compare the expression of microRNA 27b and microRNA137 in tissues and saliva between OLP patients and controls, also, to evaluate their use as biomarkers of disease activity and malignant transformation by using real-time quantitative PCR. Our result showed down expression in miRNA27b and miRNA137 in tissue and saliva of OLP compared to control, denoting the role of miRNA27b and miRNA137 in the pathogenesis and potential malignant transformation of OLP. In conclusion, the down expression of salivary miRNA27b and miRNA137 favor the use of saliva sample as a noninvasive method for monitoring OLP activity and malignant transformation | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aMicroRNA 137 | |
| 653 | 4 | _aMiRNA27b | |
| 653 | 4 | _aOral lichen planus | |
| 700 | 0 |
_aOlfat Gamil Shaker , _eSupervisor |
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| 700 | 0 |
_aShahira Gamal Elashiry , _eSupervisor |
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| 700 | 0 |
_aSoheir Mohamed Gaafar , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c63581 _d63581 |
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