000			03402cam a2200349 a 4500
003			EG-GiCUC
005			20250223031925.0
008			180205s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.28.Ph.D.2017.Om.R
100	0		_aOmar Hosni Dwidar
245	1	4	_aThe role of the mother-daughter genetic and environmental relationship in central obesity / _cOmar Hosni Dwidar ; Supervised Abeer Atef Elashmawi , Nayera Elmorsi Hassan , Waheeba Ahmed Zarouk
246	1	5	_aدور العلاقات الوراثية و البيئية الخاصة بالأم و ابنتها في السمنة المركزية
260			_aCairo : _bOmar Hosni Dwidar , _c2017
300			_a250 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aCentral obesity is an important predictor of all-cause mortality. Children of obese parents bear a greater risk to develop obesity themselves. The rising frequency of obesity in children highlights the importance of environmental factors such as eating behaviors. Our objective was to find possible correlations in central obesity and other cardio-metabolic parameters between mother and daughter. Subjects and Methods The current study measured anthropometric, laboratory, radiologic, and genetic data for 120 centrally obese mothers and their 200 daughters aged from 12 to 18 years old. Familial associations for central obesity and other non-communicable disease risk factors were assessed. Results Thirty-two percent of the group of daughters were overweight, 18.0% obese and 30% had central obesity; 22.0% are already suffering from metabolic syndrome. Genotype E3/E4 of apolipoprotein E group has the highest percentage of daughters suffering from central obesity. Positive correlation was found between daughters and their mothers regarding central obesity indices. Umbilical visceral fat of mothers was positively correlated with waist to hip ratio and LDL of daughters. Both waist and hip circumferences of mothers was positively correlated to HDL of daughters. A positive correlation was also noticed between mothers{u2019} LDL and daughters{u2019} waist-height ratio. Mothers{u2019} insulin and insulin resistance was positively correlated to daughters{u2019} triceps skinfold thickness as well as visceral umbilical fat. Correlations for some other non-communicable disease risk factors were also significant. Significant strong positive correlations showed between eating precooked/froze /fried food and suprailiac skinfold thickness; negative correlations between eating vegetables, fruits and both triceps and biceps skinfold thickness were apparent. Conclusion A key role could be played by the mother in the primary prevention of central obesity due to the consistent association of central obesity indices between mothers and daughters
530			_aIssued also as CD
653		4	_aCardiometabolic risk factors
653		4	_aCentral obesity
653		4	_aFamily
700	0		_aAbeer Atef Elashmawi , _eSupervisor
700	0		_aNayera Elmorsi Hassan , _eSupervisor
700	0		_aWaheeba Ahmed Zarouk , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c64864 _d64864