000			03581cam a2200349 a 4500
003			EG-GiCUC
005			20250223031950.0
008			180331s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.28.Ph.D.2017.Ra.O
100	0		_aRasha Rady Mohamed Mohamed Ali
245	1	0	_aOxidant {u2013}antioxidant status in sickle cell disease patients in relation to Trans-cranial Doppler (TCD) Velocities and Estimated Systolic Pulmonary Artery Pressure (ESPAP) / _cRasha Rady Mohamed Mohamed Ali ; Supervised Khaled Mohamed Salama , Mona Kamal Elghamrawy , Rodina Sobhy
246	1	5	_aالأكسدة ومضادات الأكسدة عند مرضى أنيميا الخلايا المنجلية و علاقتها بسرعة الدم فى شرايين المخ والضغط فى الشريان الرئوى
260			_aCairo : _bRasha Rady Mohamed Mohamed Ali , _c2017
300			_a131 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: A Chronic pro-inflammatory state exists in sickle cell disease (SCD) patients, even in the clinically asymptomatic phase. In SCD patients, the relation between the chronic pro-inflammatory state and oxidative stress is bidirectional. Aim of work: Assessment of the oxidant {u2013}anti oxidant status in SCD patients in its relation to transcranial Doppler (TCD) velocities and estimated pulmonary artery pressure (ESPAP). Patients and Methods: This case-control study included 78 SCD patients (31 SS, 47 SB) in steady state as well as 40 age and sex matched healthy controls. Serum nitrite, malondialdhyde (MDA), paraoxinase (PON), catalase and total antioxidant capacity (TOA) were estimated calorimetrically.TCD was done via transtemporal approach according to STOP trial and pulmonary hypertension was assessed as an estimate from tricuspid regurge (TR) jet velocity using the modified Bernoulli equation. Results: Serum nitrite and serum MDA were significantly higher in cases than controls (P {u02C2}0.01, {u02C2}0.01, respectively) while serum catalase and serum PON and TOA were significantly lower in cases than controls (P=0.03, {u02C2}0.01, {u02C2}0.01, respectively). Serum nitrite showed significant negative correlation with TOA and serum catalase (P {u02C2}0.01, 0.03 respectively). Serum PON showed significant negative correlation with age of patient, age at 1st dose of hydroxyurea (HU) among all patients (P{u02C2}0.05,{u02C2}0.05 respectively).TOA significantly correlated to TCD velocities in right dICA among all patients and SB patients(P{u02C2}0.05, {u02C2}0.01 respectively). Among SS group, serum nitrite significantly correlated to Hb F (P{u02C2}0.05) while serum catalase showed statistically significant negative correlations with Hb F (P {u02C2}0.05). Among SB group, serum PON showed significant negative correlation with duration of chelation (P{u02C2}0.05) and significantly correlated to Hb F (P{u02C2}0.05). No correlation was found between all measured oxidants-antioxidants and ESPAP among our patients
530			_aIssued also as CD
653		4	_aOxidants
653		4	_aSCA
653		4	_aTrans-cranial Doppler
700	0		_aKhaled Mohamed Salama , _eSupervisor
700	0		_aMona Kamal Elghamrawy , _eSupervisor
700	0		_aRodina Sobhy , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c65661 _d65661