000			02804cam a2200349 a 4500
003			EG-GiCUC
005			20250223031955.0
008			180412s2017 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.02.M.Sc.2017.Ka.B
100	0		_aKarima Mahmoud Nasraldin
245	1	0	_aBiochemical study of Human Chitinase3-like 1 in liver diseases / _cKarima Mahmoud Nasraldin ; Supervised Abdelgawad Ali Fahmi , Mohamed Ali Eldesouky , Aisha Eid
246	1	5	_aدراسة كيميائيه حيوية لكيتيناز 3 مشابه-1 الإنسانى فى أمراض الكبد
260			_aCairo : _bKarima Mahmoud Nasraldin , _c2017
300			_a139 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aThe aim of this study was to assess the performance of serum YKL-40 (Human Chitinase 3-like 1) as a diagnostic Biomarker and its discriminating power between different liver diseases. And assessment of the diagnostic value of serum YKL-40 (direct marker) independently and in combination with some of the well-known (non-invasive) indirect markers by our new combination score ( KLT score ) , and study if this combination leading to diagnostic power improvement and their AUCs elevation or not.to fulfill the target of this study , a total of 88 serum samples were collected from El kasr el Ainy ,Abdulkadir Fahmy and el Andalusia Hospital in Egypt ,the age ranges between 40 to 65 years old they classified into 4 groups : group 1 included 20 patients with (HCC) , group 2 including 28 patients with( cirrhosis) , group 3 included 20 patients with (HBV ) , group 4 included 20 patients with (HCV ). The results of the patients were compared to the results of 20 age and sex matched subjects who served as control group. Our study revealed that to differentiate between ( cirrhosis and HCC)& diagnose HBV (control and HBV ) our new established ( KLT score ) is the best for this discrimination as we found that KLT score had the best AUC in comparison to dependent serum YKL-40 ,using KLT score showed improved sensitivity , specificity ,PPV than dependent serum YKL-40 . And we found that for discrimination between (HCV and HBV) & (HBV and Cirrhosis) dependent serum YKL-40 had the best AUC followed by KLT score
530			_aIssued also as CD
653		4	_aHBV
653		4	_aHCV
653		4	_aYKL-40
700	0		_aAbdelgawad Ali Fahmi , _eSupervisor
700	0		_aAisha Eid , _eSupervisor
700	0		_aMohamed Ali Eldesouky , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aEnas _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c65840 _d65840