| 000 | 03176cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223031957.0 | ||
| 008 | 180417s2017 ua h f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.20.Ph.D.2017.Re.S | ||
| 100 | 0 | _aRehab Magdy Hassan | |
| 245 | 1 | 0 |
_aSpotlight on early predictors of progressive multiple sclerosis : _bNeuro-cognitive, genetic and optical coherence tomography studies / _cRehab Magdy Hassan ; Supervised Maged Mohammed Abdelnaseer , Shereen Fathi Sheir , Nagwa Kamal Eldin Roshdy |
| 246 | 1 | 5 |
_aإلقاء الضوءعلى تنبؤات مبكرة للتصلب المتعدد التقدمى : _bدراسة الوظائف المعرفية: و الصفات الوراثية و التصويرالمقطعى للتماسك البصرى |
| 260 |
_aCairo : _bRehab Magdy Hassan , _c2017 |
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| 300 |
_a194 P. : _bfacsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery | ||
| 520 | _aIdentification of MS patients with a high risk for progression has been a challenge for decades. Objective: To determine the role of neuro-cognitive, genetic and optical coherence tomography (OCT) on multiple sclerosis (MS) disease progression. Subjects and methods: Two groups of definite MS patients, relapsing remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), each with 25 patients, were submitted to a battery of neuropsychological tests, OCT and glutamate N-methyl-D-aspartate receptors (NMDARs) gene studies. Results: The best predictor for progressive MS is SDMT (symbol digit modality test) (P value 0.021), that is dependent statistically on the educational level of the MS patient (P value 0.016). The most specific and sensitive test in discrimination between RRMS and SPMS groups is provided through OCT via thickness of average RNFL (retinal nerve fiber layer). Eighty three percent of MS patients with CC genotype reported frequent previous attacks of optic neuritis with significant marked thinning in RNFL and GCC (ganglion cell complex) despite of their higher cognitive performance in comparison to other genotypes. Conclusions: An early deficit in information processing speed measured by SDMT is a good predictor of early transition to SPMS. Thicknesses of RNFL of 83.65om and GCC of 77.47om are indications for induction therapy to prevent transitioning to secondary progressive phase with high sensitivity; 91.7% and 87.5% respectively. Finally, presence of CC genotype of glutamate NMDARs gene predicts frequent optic neuritis episodes with marked visual loss, although the same genotype may preserve cognitive functions | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aMultiple sclerosis | |
| 653 | 4 | _aOptic neuritis | |
| 653 | 4 | _aSDMT | |
| 700 | 0 |
_aMaged Mohammed Abdelnaseer , _eSupervisor |
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| 700 | 0 |
_aNagwa Kamal Eldin Roshdy , _eSupervisor |
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| 700 | 0 |
_aShereen Fathi Sheir , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c65905 _d65905 |
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