000 03344cam a2200349 a 4500
003 EG-GiCUC
005 20250223032050.0
008 180927s2018 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.36.Ph.D.2018.Le.C
100 0 _aLegaa Ali Mohammad Elmekkawy
245 1 0 _aCognitive assessment in excessive daytime sleepiness :
_bElectrophysiological study /
_cLeqaa Ali Mohammad Elmekkawy ; Supervised Mona M. Abdelmonem Nada , Eman Ahmed Maher , Mye Ali Basheer
246 1 5 _aالتقييم المعرفي لمرضى النُعاس النَهاري المُفرط :
_bدراسة كهروفسيولوجية
260 _aCairo :
_bLeqaa Ali Mohammad Elmekkawy ,
_c2018
300 _a148 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurophysiology
520 _aIntroduction : Excessive daytime sleepiness (EDS) is considered the most common sleep-related symptom affecting 20 % of the population and represents a major public health problem. The most common cause of EDS in the clinical setting is obstructive sleep apnea (OSA). Normal sufficient sleep is essential for sound cognitive functions in the subjects.Purpose: This study aimed to the electrophysiological assessment of cognition and sleepiness, in patients suffering from excessive daytime sleepiness (EDS) and finding the correlation between them; (the electrophysiological tools used in cognition and EDS assessment), aiming at potential integration of these electrophysiological tests as diagnostic tools for cognition and EDS.Methods: Forty subjects participated in the study, were divided into two groups: a case group (twenty patients) and a control group (twenty subjects). All participants were subjected to complete clinical evaluation in addition to sleepiness and cognitive assessment using Epworth sleepiness scale (ESS), Mini-Mental State Examination (MMSE), Polysomnography (PSG) once, while Karolinska sleepiness scale (KSS), Trail Making Test (TMTA&B), P300, QEEG were done before and after sleep.Results: The case group showed a statistically highly significant more prolonged P300 (Cz) latency and reaction time (RT) (P <0.001), in addition to reduction of average absolute power (oV2) of occipital alpha (P <0.025) and central (Cz) and temporal delta (p=0.044) after sleep than values before it. Also there was significant positive correlation between the difference of average occipital (O) alpha with (ESS) and with (KSS before sleep).Conclusion: Patients with EDS have electrophysiologic evidence of cognitive affection, as assessed by P300 and QEEG. This finding runs with the suggestion of the use of QEEG as objective tool for sleepiness and cognitive assessment especially when recorded before and after sleep
530 _aIssued also as CD
653 4 _aCognition{u2013}Quantitative
653 4 _aExcessive daytime sleepiness (EDS)
653 4 _aObstructive sleep apnea (OSA)
700 0 _aEman Ahmed Maher ,
_eSupervisor
700 0 _aMona Mohamed Abdelmonem Nada ,
_eSupervisor
700 0 _aMye Ali Basheer ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aEnas
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c67686
_d67686