000			03045cam a2200349 a 4500
003			EG-GiCUC
005			20250223032108.0
008			181029s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2018.Na.E
100	0		_aNashwa Ahmed Tharwat
245	1	4	_aThe evaluation of carotid intima-media thickness and endothelial dysfunction in clinical and subclinical hypothyroidism / _cNashwa Ahmed Tharwat ; Supervised Aasem Mohamed Saif Eldin , Alaa Mahmoud Abdelelhamid , Shrouk Mohamed Ahmed Mousa
246	1	5	_aقياس سمك بطانة الشريان السباتي وتقيم بطانة الاوعية الدموية في مرضي قصور الغدة الدرقية السريري ودون السريري
260			_aCairo : _bNashwa Ahmed Tharwat , _c2018
300			_a153 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aBackground: Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic fat infiltration by >5% of hepatocytes, as assessed by liver biopsy, NAFLD is now considered the most prevalent form of chronic liver disease, affecting approximately 10%{u2013}20% of the general pediatric population. Aim of work: The aim of this study was to determine prevalence of each of the causes of secondary NAFLD. Patients and methods: A final number of 66 patients presented with biopsy proven macrovesicular steatosis in the period from 2010 {u2013} 2015 to the Pediatric Hepatology Unit, Cairo University , Children's Hospital, whom their data were retrospectively analyzed for the etiology, clinical presentation, history, initial laboratory investigations, abdominal ultrasonography and their biopsy data. Results: The median age of presentation was 2.7 years with more prevalence in boys (65.2%), the commonest presentation was abdominal distention (69.7%). Biopsy revealed preserved lobular architecture in 50 biopsies (75.7%). The inflammation and fibrosis were mainly in the portal areas (90.9%). The study revealed that the commonest diagnosis was GSD (33.3%) followed by HCV infection (10.6%) then Chanrin-dormann syndrome 9.1%. Conclusion: There is a higher prevalence of secondary causes of NAFLD in patients younger than 10 years old, with higher degree of steatosis in younger patients and chanarin dorfmann patients show more fibrosis and steatosis than other diagnoses. In this study GSD was the commonest cause of secondary NAFLD
530			_aIssued also as CD
653		4	_aCarotid intima-media thickness
653		4	_aEndothelial dysfunction
653		4	_aHypothyroidism
700	0		_aAasem Mohamed Saif Eldin , _eSupervisor
700	0		_aAlaa Mahmoud Abdelelhamid , _eSupervisor
700	0		_aShrouk Mohamed Ahmed Mousa , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c68241 _d68241