000			02936cam a2200349 a 4500
003			EG-GiCUC
005			20250223032132.0
008			181212s2017 ua dho f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.09.Ph.D.2017.Sa.C
100	0		_aSara Ibrahim Attia Mohamed
245	1	0	_aComparative study of 3D composite scaffolds containing some inorganic ingredients for hepatic cell regeneration / _cSara Ibrahim Attia Mohamed ; Supervised Afaf Abdelrazek , Afaf Elsaeed Mahgoub , Amany Abdelmoniem Mostafa
246	1	5	_aدراسة مقارنة لحاملات حيوية ثلاثية الابعاد تحتوى على بعض المكونات غير العضوية لتجديد خلايا الكبد
260			_aCairo : _bSara Ibrahim Attia Mohamed , _c2017
300			_a91 P. : _bcharts , facsimiles , photographs ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry
520			_aHydroxyapatite (HA) is a biocompatible material with high binding activity to DNA and protein. Also, its lattice is eligible for substition in both Ca and P sites. Thus, Ca can be substituted by Sr, Na, and Fe while P is easily substituted by CO₃, Si and Se. Incorporation of selenium which is known to play a specific role in human health, may endow the materials with novel characteristics. Therefore, it was selected for the present study. A series of substituted nano-hydroxyapatite with 1-5% Se, (SeHA) powders were synthesised by an aqueous precipitation method using sodium selenite. The produced precipitates were dried at 60{u00B0}C. The dried ground powders were characterised by XRF, XRD, FTIR and TEM. The XRD patterns obtained confirm the substitution of Se ions in the crystal lattice of HA and was accompanied by the presence of Na ion as was detected by XRF; (SeHA1, SeHA1.5, SeHA2, SeHA2.5, SeHA3 and SeHA5). No change in the morphology of the rod shaped particles took place. Instead a reduction in their size was observed with increase in the selenium content. The cytotoxicity of the produced powders was evaluated in vitro on human bone marrow mesynchymal stem cells (BM-MSCs) and umbilical cord derived mesenchymal stem cells (UC-MSCs). The 0.59 mM of Se corresponding to 2% substitution in the lattice of HA (SeHA2) does not show cytotoxicity and stimulated the proliferation of UC-MSCs in contrast to pure HA powders which inhibited proliferation of the same cells
530			_aIssued also as CD
653		4	_aHydroxyapatite
653		4	_aScaffolds
653		4	_aSelenium
700	0		_aAfaf Abdelrazek , _eSupervisor
700	0		_aAfaf Elsaeed Mahgoub , _eSupervisor
700	0		_aAmany Abdelmoniem Mostafa , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c69047 _d69047