000			02153cam a2200349 a 4500
003			EG-GiCUC
005			20250223032154.0
008			190127s2018 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.04.M.Sc.2018.Ne.S
100	0		_aNehal Mohamed Nabil Elbakhshawangy
245	1	0	_aSynthesis of novel oxadiazole and chromene derivatives as cytotoxic agents / _cNehal Mohamed Nabil Elbakhshawangy ; Supervised Azza Taher Taher Shalaby , Hala Bakr Ali Elnassan , Asmaa Elsayed Abdellatief Kassab
246	1	5	_aتشييد مشتقات جديدة من الأوكساديازول و الكرومين كمضادات للأورام
260			_aCairo : _bNehal Mohamed Nabil Elbakhshawangy , _c2018
300			_a140 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
520			_aThe design and synthesis of 1,3,4-oxadiazoles and chromenopyrimidines as microtubule destabilizing agents has been explained. The newly synthesized compounds were evaluated for their cytotoxicity against MCF-7 cell line. All the prepared chromenopyrimidines showed potent cytotoxic activity. Compound XVb was the leading compound as it showed IC₅₀ values of 0.13 oM on tumor cell line MCF-7 (11-fold more active than the reference drug colchicine) and 14.06 oM on mammary epithelial cell line MCF-10A. Also, it inhibited tubulin polymerization (IC₅₀ = 8.36oM), caused cell cycle arrest at G2/M phase (five folds more than control) and cellular apoptosis. Moreover, it increased the level of active caspase-3, 12-fold compared with control.
530			_aIssued also as CD
653		4	_aChromene derivatives
653		4	_aCytotoxic agents
653		4	_aNovel oxadiazole
700	0		_aAsmaa Elsayed Abdellatief Kassab , _eSupervisor
700	0		_aAzza Taher Taher Shalaby , _eSupervisor
700	0		_aHala Bakr Ali Elnassan , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c69771 _d69771