000			02881cam a2200349 a 4500
003			EG-GiCUC
005			20250223032157.0
008			190131s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.18.Ph.D.2018.Ah.R
100	0		_aAhmed Mohammed Shennawy
245	1	0	_aRole of serum Nogo{u2013}B in evaluation of hepatic decompensation in cirrhotic patients compared to traditionally used methods / _cAhmed Mohammed Shennawy ; Supervised Ayman Mohammed Fouad , Wael Mohammed Aref , Hadeel Mohammed Elhanafi
246	1	5	_aدور مادة النوجو- ب في تقييم المخزون الوظيفي الكبدي المتبقي في مرضي تشمع الكبد مقارنة بالطرق التقليديه المستخدمه
260			_aCairo : _bAhmed Mohammed Shennawy , _c2018
300			_a111 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aIntroduction:Liver fibrosis is a part of the structural and functional changes in most of chronic liver diseases.It was considered as an irreversible process, but now it is proved to be a dynamic process with the potential for significant resolution. Extracellular matrix(ECM) components accumulate in the liver as a result of imbalances in their production and degradation progressingultimately to cirrhosis.(Cho SW et al, 2007) Prognosis of patients with liver cirrhosis often depends on their hepatic functional reserve.For many years, liver biopsy was considered the golden test for staging of hepatic fibrosis. Since it is associated with many complications, blood tests for assessment of hepatic fibrosis were studied including indirect tests based on routine liver function parameters, direct tests based on extracellular matrix proteins.(Nguyen-Khac E and Capron D, 2006) Nogo-B and the reticulum (Rtn) family, including Rtn1, Rtn2, Rtn3 and Rtn4, are primarily localized in the endoplasmic reticulum.(Oertle Tand Schwab ME.2003)Nogo-B is encoded by gene Rtn4, with two other isoforms, Nogo-A and Nogo-C. Nogo-B is expressed widely in tissues like liver, kidney, and lung(Zhang D, et al. 2011) Playinga critical role in vascular remodeling(Acevedo L, et al. 2004), cell migration and proliferation. (Yu J, et al. 2009)However, its role in the liver and liver cancers is not fully understood
530			_aIssued also as CD
653		4	_aChild-Pugh
653		4	_aLiver fibrosis/cirrhosis
653		4	_aNogo-B
700	0		_aAyman Mohammed Fouad , _eSupervisor
700	0		_aHadeel Mohammed Elhanafi , _eSupervisor
700	0		_aWael Mohammed Aref , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c69875 _d69875