000			02833cam a2200349 a 4500
003			EG-GiCUC
005			20250223032211.0
008			190219s2018 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.24.03.Ph.D.2018.Is.S
100	0		_aIslam Mohamed Noaman Mohamed
245	1	0	_aStudy of the treatment of cutaneous fungal infection in animal model using photoactivated composite of methylene blue and metal nanoparticle / _cIslam Mohamed Noaman Mohamed ; Supervised Mona Mohamed Soliman , Abeer Attia Tawfik ,Hassan Ibraheem H. Elsayyad
246	1	5	_aعلاج الفطريات الجلدية في نموذج حيواني باستخدام مركب الميثيلين الأزرق وجسيمات النانو المعدنية المستحثة بالضوء
260			_aCairo : _bIslam Mohamed Noaman Mohamed , _c2018
300			_a78 P. : _bfacsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Applications in Medical and Biological
520			_aBackground: Onychomycosis is a widespread public health problem, in which T. rubrum and T. mentagro-phytes is the commenest causative organisms. Current medical therapy has many drawbacks and sideeffects. Methylene blue (m.b) photodynamic therapy (pdt) proved efficacy but with lengthy sessions.Objectives: Optimizing methylene blue photodynamic therapy by combination of methylene blue pho-tosensitizer and gold nanoparticles (aunps) in a composite as gold nanoparticles are efficient delivery systems and efficient enhancers of photosensitizers for antifungal photodynamic therapy. Materials and methods: Eighty newzealand rabbit (Oryctolagus cuniculus) were used and categorized ineight equal groups as follows; healthy and infection control, composite photodynamic therapy and five comparative groups. Photodynamic therapy was initiated at day three to five post inoculation, for four sessions forty-eight hours apart. Each group divided and light exposure at two fluencies; 80 J and 100 J. All groups were investigated macroscopically and microscopically (histopathology and scanning electron microscope) also flowcytometry assessment for cell death and X-ray analysis for gold nanoparticles accumulation in brain and liver tissues were determined
530			_aIssued also as CD
653		4	_aDermatophytosis
653		4	_aMethylene blue photodynamic therapy
653		4	_aOnychomycosis
700	0		_aAbeer Attia Tawfik , _eSupervisor
700	0		_aHassan Ibraheem H. Elsayyad , _eSupervisor
700	0		_aMona Mohamed Soliman , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c70329 _d70329