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008 190302s2018 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.17.M.Sc.2018.Am.O
100 0 _aAmr Muhammed Rakha
245 1 0 _aOxidative stress status and dna damage on occupational exposure to polycyclic aromatic hydrocarbons among coal tar workers /
_cAmr Muhammed Rakha ; Supervised Sawsan Farouk Helal , Laila Ahmed Rashed , Rehab Shehata Abdelhady
246 1 5 _aالتوتر التأكسدي و تضرر الحمض النووى مع التعرض المهني للبولي اروماتك هيدروكاربونات في عمال قطران الفحم
260 _aCairo :
_bAmr Muhammed Rakha ,
_c2018
300 _a203 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Industrial and Occupational Disease
520 _aIntroduction: Polyaromatic hydrocarbons (PAHs) are of occupational and environmental concern as they are toxic, carcinogenic, mutagenic, and/or teratogenic (causing birth defects) and even are probable human carcinogens.Objective: To assess the health effects of occupational exposure to PAHs on DNA damage and oxidative stress. Methods: A group of 40 coal tar workers and another 40 matched control were subjected to full history and clinical examination,estimation of 1-hydroxypyrene (1-OHPyrene) level in urine, Benzopyrene-DNA adducts, oxidative stress enzymes (Superoxide dismutase and glutathione peroxidase),Cytochrome P450 and Complete blood picture. Results: Statistically significant higher level of 1-OHPyrene, DNA adducts and lower levels of superoxide dismutase and glutathione peroxidase were detected among the exposed workers compared to the control group. Conclusion: oxidative stress and DNA damage might be among the hazards that can be attributed to occupational exposure to PAHs among coal tar workers
530 _aIssued also as CD
653 4 _a1-Hydroxypyrene
653 4 _aCoal tar production
653 4 _aPolycyclic aromatic hydrocarbons
700 0 _aLaila Ahmed Rashed ,
_eSupervisor
700 0 _aRehab Shehata Abdelhady ,
_eSupervisor
700 0 _aSawsan Farouk Helal ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c70594
_d70594