| 000 | 02767cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032221.0 | ||
| 008 | 190305s2018 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.18.M.Sc.2018.Na.G | ||
| 100 | 0 | _aNashwa Mohamed Nor Eldin AboElsoad | |
| 245 | 1 | 0 |
_aGene expression of vanin-1 (VNN-1) in Egyptian adults with immune thrombocytopenia ITP / _cNashwa Mohamed Nor Eldin AboElsoad ; Supervised Alia Abdelaziz Ayad , Doaa Mohamed Eldemerdash , Rania Elsayed Hussein |
| 246 | 1 | 5 | _aتقدير مستوى جين الفانين 1 فى المرضى البالغين المصريين الذين يعانون من مرض نقص الصفائح الدموية المناعى |
| 260 |
_aCairo : _bNashwa Mohamed Nor Eldin AboElsoad , _c2018 |
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| 300 |
_a105 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine | ||
| 520 | _aBackground: Distinguishing self-limited acute ITP from chronic ITP identify potential targets for therapeutic interventions in the group at risk for chronic ITP. Overproduction free radical in the absence of adequate antioxidant defense may cause irreversible changes to biomolecules and the generation of neo-antigenic determinants. This may ultimately contribute to epitope spreading and the abrogation of self-tolerance. Vanin-1 (VNN1) has been proven to be an oxidative stress sensor, which regulates endogenous glutathione levels. Objectives: to find an association between overexpressed VNN1 in blood and progression to chronic ITP. Method: The study was carried out on 40 cases and 10 healthy controls patients were grouped into: Group A: 30 patients with acute ITP Group B: 10 patients with chronic ITP. All patients were subjected to Vanin1 gene level by PCR technique. Results: Vanin1 gene was higher in patients with ITP than control with statistically significant values, (P-value< 0.001) vanin1 gene was higher in acute than chronic patients but the difference was statistically insignificant, (P value >0.05) .correlation between vanin1 gene and hemoglobin, leucocytic count and platelet count before treatment in group B (chronic ITP)and groups A (responder and non-responders) were statistically insignificant | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aEgyptian adults | |
| 653 | 4 | _aITP | |
| 653 | 4 | _aVanin1 gene | |
| 700 | 0 |
_aAlia Abdelaziz Ayad , _eSupervisor |
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| 700 | 0 |
_aDoaa Mohamed Eldemerdash , _eSupervisor |
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| 700 | 0 |
_aRania Elsayed Hussein , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c70659 _d70659 |
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