| 000 | 02699cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032253.0 | ||
| 008 | 190504s2018 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.03.Ph.D.2018.Sa.R | ||
| 100 | 0 | _aSara Sayed kadry Abdallah | |
| 245 | 1 | 0 |
_aRole of microRNA-155 on modulating the function of T-helper 17 cells in lichen planus / _cSara Sayed kadry Abdallah ; Supervised Laila Ahmed Rashed , Rania Mounir Abdelhay , Heba Mohammed Abdelhafiz Morsy |
| 246 | 1 | 5 | _aدور الحامض النووى الريبوزى متناهى الصغر {u٠٦ئ١}٥٥فى التعديل الوظيفي لخاليا تى {u٠٦ئ١}{u٠٦ئ١} المساعدة فى مرض الحزاز السطحى |
| 260 |
_aCairo : _bSara Sayed kadry Abdallah , _c2018 |
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| 300 |
_a137 P. : _bcharts ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry | ||
| 520 | _aLichen Planus (LP) is a dermatological disease affecting skin and / or mucous membranes. Among the various miRNAs playing a possible role in the control of the immune response, MicroRNA-155 is one of the MicroRNAs (miRNAs) that emerged as key regulator of the immune system, and it may have a role in the pathogenesis or the prognosis of many diseases including lichen planus. The aim of this study is to detect expression of MiRNA-155 and its possible effect on Th-17 cells by estimating level of Interleukin-17 and Interleukin-22 levels in patients with Lichen Planus. This study was done on 60 patients of lichen planus and 30 healthy controls classified into three groups, group 1: including 30 control healthy subjects, group 2: 30 oral lichen planus cases and group 3: 30 cutaneous lichen planus patients. MiRNA-155 level was estimated by Real-time PCR. Serum levels of IL-17 and IL-22 were measured by enzyme linked Immunosorbent assay (ELISA). Patients with lichen planus showed increased expression of MiRNA-155 relative to controls, elevated level of IL-17 and IL-22 compared to controls, MiRNA-155, IL-17 and IL-22 were positively correlated to each other, they also positively correlated to duration of the disease in case of cutaneous type | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aIL-17 | |
| 653 | 4 | _aLichen planus | |
| 653 | 4 | _aMiRNA-155 | |
| 700 | 0 |
_aHeba Mohammed Abdelhafiz Morsy , _eSupervisor |
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| 700 | 0 |
_aLaila Ahmed Rashed , _eSupervisor |
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| 700 | 0 |
_aRania Mounir Abdelhay , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aSamia _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c71748 _d71748 |
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