000			02165cam a2200349 a 4500
003			EG-GiCUC
005			20250223032254.0
008			190405s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.04.M.Sc.2018.Re.S
100	0		_aReham Sayed Ibrahim
245	1	0	_aSynthesis of some new pyrazole and pyrazolopyrimidine derivatives of expected analgesic and antiinflammatory activity / _cReham Sayed Ibrahim ; Supervised Afaf Kamal Eldin Elansary , Ehab Mohamed Gedawy , Elham Azz Elarab
246	1	5	_aتشييد بعض مركبات البيرازول ومشتقات البيرازولوبيرمدين الجديده ذات تاثير مسكن متوقع و مضاد للالتهاب
260			_aCairo : _bReham Sayed Ibrahim , _c2018
300			_a138 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry
520			_aNovel pyrazole and pyrazolo[3,4-d]pyrimidine derivatives were prepared and evaluated for their analgesic activity. The most potent compounds V,Vb, IX, XIId, XIIIc,d, XIVa, XV were further evaluated for their antiinflammatoryactivity. Compounds VIb, IX, XIIIc,d were further evaluated for their ulcerogenic activity. Compounds VIb, IX, XIIId undergo in-vitro COX-II inhibitory activity assay. All Final prepared compounds were studied by molecular docking studies. Compound VIb showed both high analgesic, antiinflammatory, no ulcerogenic effect in addition to its higher selectivity index for COX-II enzyme with SI = 5.1 when comparing to celecoxib with SI = 6.2 exhibiting moderate binding energy -24.12 score Kcal/mol
530			_aIssued also as CD
653		4	_aAntiinflammatory activity
653		4	_aPyrazole
653		4	_aPyrazolopyrimidine
700	0		_aAfaf Kamal Eldin Elansary , _eSupervisor
700	0		_aEhab Mohamed Gedawy , _eSupervisor
700	0		_aElham Azz Elarab , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c71756 _d71756