000			02904cam a2200349 a 4500
003			EG-GiCUC
005			20250223032255.0
008			190505s2018 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.10.M.Sc.2018.Do.E
100	0		_aDoaa Mostafa Kamel Ahmed
245	1	0	_aEstimation of level of erap1 expression in lesional and non lesional skin of psoriatic patients and healthy controls / _cDoaa Mostafa Kamel Ahmed ; Supervised Dina Metwally Salama , Rana Fathy Hilal , Amul Mohamed Abdelrahim Badr
246	1	5	_aتقييم مستوى انزيم الشبكة الأندوبلازمية أمينوببتيداز1 فى الجلد لمرضى الصدفية
260			_aCairo : _bDoaa Mostafa Kamel Ahmed , _c2018
300			_a132 P. : _bfacsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venereology
520			_aBackground: Psoriasis is a chronic, inflammatory autoimmune disease of the skin, characterized by keratinocyte hyper proliferation and resulting in erythematous, scaly plaques. The association of enzymes involved in the final processing of MHC-I ligands with inflammatory diseases was reported and the association of ERAP1 in psoriasis was reported. Objectives: Estimation of level of ERAP1 expression in lesional and non lesional skin of psoriatic patients and healthy controls and its role in pathegenesis of psoriasis. Patients and methods: Twenty-five psoriatic patients and thirty healthy controls were enrolled in this study. All patients were subjected to detailed history and clinical examination to determine severity (PASI score) of psoriasis. Skin biopsies were obtained from all subjects, one from lesional and other from non lesional skin of psoriatic patients and one from the healthy controls. ERAP1 level was measured using PCR technique. Results: Results revealed a higher level of expression of ERAP1 between psoriatic patients and controls regarding tissue lesional and non- lesional ERAP1 level (p values<0.001). Positive corrrelation was detected between psoriatic patients and healthy controls regarding tissue ERAP1 level. In addition, there was statistically significant difference between lesional ERAP1, non-lesional ERAP1 and PASI score (p value<0.001) and positive correlation between lesional and non-lesional ERAP1 level in psoriatic patients and PASI score
530			_aIssued also as CD
653		4	_aAntigen processing
653		4	_aPsoriasis
653		4	_aTissue lesional ERAP1
700	0		_aAmul Mohamed Abdelrahim Badr , _eSupervisor
700	0		_aDina Metwally Salama , _eSupervisor
700	0		_aRana Fathy Hilal , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c71808 _d71808