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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.10.M.Sc.2019.Ay.A
100 0 _aAya Ihab Ismail
245 1 0 _aAssessment of serum prolactin, tissue prolactin as well as tissue prolactin receptor in patients with vitiligo /
_cAya Ihab Ismail ; Supervised Ghada Mohamed Elhanafi , Heba Ahmed Mohamed Abdelkader , Olfat Gamil Shaker
246 1 5 _aتقييم مستوي هرمون البرولاكتين في مصل الدم و الأنسجة وكذلك مستوي مستقبلات البرولاكتين بالأنسجة في المرضى الذين يعانون من البهاق
260 _aCairo :
_bAya Ihab Ismail ,
_c2019
300 _a108 P. :
_bcharts , facsimile ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520 _aBackground:The exact cause of vitiligo remains unclear, several theories have been proposed including the autoimmune and neuroendocrine theories. Prolactin has been studied as an immunomodulatory factor in several autoimmune diseases. In the terms of vitiligo, previous studies revealed contradictory results. Aim of the work: To measure the level of serum and tissue prolactin as well as prolactin receptor expression in vitiligo, in an attempt to verify their possible role in its pathogenesis. Patients and methods: A case control study was conducted on 40 subjects; 20 patients with vitiligo and 20 age, sex and skin type matched healthy controls. Blood samples were taken from them to determine the serum prolactin level (ng/ml). Skin biopsies were obtained from the lesional skin of patients and normal skin of controls to determine the level of tissue prolactin(ng/mg) as well as prolactin receptor expression (ng/gm)
530 _aIssued also as CD
653 4 _aProlactin
653 4 _aProlactin receptors
653 4 _aVitiligo
700 0 _aGhada Mohamed Elhanafi ,
_eSupervisor
700 0 _aHeba Ahmed Mohamed Abdelkader ,
_eSupervisor
700 0 _aOlfat Gamil Shaker ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c73172
_d73172