000			02836cam a2200325 a 4500
003			EG-GiCUC
005			20250223032337.0
008			190730s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.10.Ph.D.2019.Sa.S
100	0		_aSalwa Magdy Ahmed Eldaly
245	1	0	_aSynthesis of some new mono and bis-heterocyclic compounds with anticipated biological activity from laboratory available starting materials / _cSalwa Magdy Ahmed Eldaly ; Supervised Fathy Mohamed Abdelrazek
246	1	5	_aتشييد بعض المركبات احادية و ثنائية الحلقة غير المتجانسة الجديدة ذات نشاط بيولوجى متوقع من بادئات متوافرة معمليا
260			_aCairo : _bSalwa Magdy Ahmed Eldaly , _c2019
300			_a264 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aPart I: Synthesis of Mono - Heterocyclic Compounds: N-(4-cinnamoylphenyl)-2-cyanoacetamide 2 underwent Kn{u04E7}venagel condensation with different derivatives of salicyaldehyde 5a-c and 8a-d to afford the respective chromene derivatives. Compound 2 reacted with malononitrile and ethyl cyanoacetate under Gewald reaction conditions to obtain the corresponding 2-aminothiophene derivatives. Enaminone derivative of compound 2 underwent reaction with each of hydrazine hydrate, guanidine and cyanoguanidine to afford di{u2013}aminopyrazole 23 and di{u2013}aminopyrimidines 24a,b respectively, also it reacted with different 3,5-diamino-4-arylazo-1H-pyrazoles 17a-e to afford the respective di{u2013}pyrazolo[1,5-a]pyrimidines 25a-f. Part II: Synthesis of Bis - Heterocyclic Compounds: N,N'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-cyanoacetamide) 53 underwent Kn{u04E7}venagel condensation with different derivatives of salicyaldehyde 5a-c affording bis chromene derivatives. Compound 53 reacted with different Ü-halocompounds to afford the corresponding bis{u2013}thiazole derivatives 61a-c. In addition to compound 53 reacted with different arylhydrazo derivatives of ethyl cyanoacetate and malononitrile to afford the bis{u2013}pyridazine derivatives 65a-d and 67a-d. Moreover, bis{u2013}aminopyrazole 70 reacted with compounds 71a-c, 73a-f and 75a-d to afford bis{u2013}pyrazolo[1,5-a]pyrimidines. Anticancer investigation and Molecular docking were performed for some newly synthesized compounds
530			_aIssued also as CD
653		4	_aBis-2-aminothiophene
653		4	_aChromene
653		4	_adi-aminopyrazole
700	0		_aFathy Mohamed Abdelrazek , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c73176 _d73176