000			02852cam a2200349 a 4500
003			EG-GiCUC
005			20250223032404.0
008			190923s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2019.Sh.I
100	0		_aShimaa Rabah Abdelmo{u2019}ez Taha
245	1	0	_aImpact of dendritic cells and natural killer cells cytokines on hepatitis C viral infection in Egyptian patients / _cShimaa Rabah Abdelmo{u2019}ez Taha ; Supervised Somaya Osman Eldeeb , Abdelrahman Zekri , Maysa Elrazky
246	1	5	_aتأثير سيتوكينات الخلايا المتشعبة والخلايا القاتلة الطبيعية على الإصابة بالإلتهاب الكبدى الفيروسى سى فى المرضى المصريين
260			_aCairo : _bShimaa Rabah Abdelmo{u2019}ez Taha , _c2019
300			_a112 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_ahelper (Th) cytokines play a key role in the immunological aspects of hepatitis C virus (HCV) pathogenesis. The pattern of Th1 (IL-2, interferon (IFN)-Þ), Th2 (IL-10), and immunomodulatory cytokines (IL-12, IL-1Ý, IFN-Ü and tumor necrosis factor-Ü receptor (TNF-ÜR2) balance participated in the outcome of host immune responses. The study aimed to investigate the serum levels of Th1/Th2 and immunomodulatory cytokines in HCV infected patients in both sexes during various liver disease stages compared to healthy controls. Blood samples were collected from 16 healthy individuals and 77 patients at different disease stages including chronic, cirrhosis, and hepatocellular carcinoma (HCC). Serum cytokine levels were measured by ELISA. Levels of serum IL-12 and IL-10 were significantly higher in both sexes in all groups than those in corresponding healthy subjects. Whereas, HCV infected female patients showed significant lower levels of IL-2, IL-1Ý, IFN-Ü in chronic and cirrhosis stages than corresponding males. Serum level of IFN-Þ could be utilized as biomarker for early detection of HCC. Finally, cytokine response variation in sex during various stages of disease, imply that the subsequent activation and attenuated functional immune responses displayed differences in the balance of Th1 and immunomodulatory related cytokines between females and males upon infection
530			_aIssued also as CD
653		4	_aCirrhosis
653		4	_aCytokines
653		4	_aGender
700	0		_aAbdelrahman Zekri , _eSupervisor
700	0		_aMaysa Elrazky , _eSupervisor
700	0		_aSomaya Osman Eldeeb , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c74080 _d74080