000			03009cam a2200337 a 4500
003			EG-GiCUC
005			20250223032431.0
008			191105s2018 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2018.Me.B
100	0		_aMenna Allah Mohamed Moghawry
245	1	0	_aBasophil count as a marker of disease activity in Egyptian children with juvenile systemic lupus erythematous / _cMenna Allah Mohamed Moghawry ; Supervised Heba Taher Othman , Amr Mohamed Salem
246	1	5	_aعدد كرات الدم القاعدية كمؤشر لنشاط مرض الذئبه الحمراء فى الاطفال المصريين المصابين بمرض الذئبة الحمراء فى مستشفى الأطفال - جامعة القاهرة
260			_aCairo : _bMenna Allah Mohamed Moghawry , _c2018
300			_a118 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aIntroduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disease, 20% of cases having their onset in childhood and are classified as juvenile-onset SLE (JSLE). Objective: The aim of this work is to assess the basophilic count as a marker for disease activity in JSLE to enable the earlier diagnosis and treatment of SLE flares. Patients and methods: This cross-sectional cohort study was conducted on 80 children with JSLE following at pediatric rheumatology clinic, Specialized Children{u2019}s hospital, Cairo University and compared to 100 healthy children as a control group. SLEDAI-2K score was done at time of the study, together with CBC with differential to evaluate basophilic count. Results: The mean age of disease onset was 9.14 ± 2.23 years. Among the clinical manifestations at presentation, arthritis and malar rash (37.5% each) were the most common. Throughout the course of the disease malar rash (70%) and nephritis (67.5%) were the most common disease manifestations. Thirty-eight patients (70.3%) did renal biopsy to diagnose nephritis. Basophil counts were similar in patients with SLE and healthy controls (0.0±0.04x109/L), p value =0.06) and was within normal range. Basophils absolute count was within normal range (0 - 0.1x 109 /L) in most of our patients. There was relative basophilia in active patients{u2019} group which increased with higher SLEDAI-2K score but with no statistical significance basophil counts were (0.01± 0.03x109/L) in SLEDAI-2K score (4-8) and were (0.03±0.07X109/L) in SLEDAI-2K score more than 8
530			_aIssued also as CD
653		4	_aBasophil counts
653		4	_aDisease activity
653		4	_aMarker
700	0		_aAmr Mohamed Salem , _eSupervisor
700	0		_aHeba Taher Othman , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aSamia _eCataloger
942			_2ddc _cTH
999			_c75005 _d75005