000			02914cam a2200349 a 4500
003			EG-GiCUC
005			20250223032437.0
008			191113s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.07.M.Sc.2019.Ma.P
100	0		_aMahmoud Mohammed Mubarek
245	1	0	_aPharmacognostical studies on gymnocarpos decandrus forssk. growing at North Western Coast in Egypt / _cMahmoud Mohammed Mubarek ; Supervised Seham Salah Eldin Elhawary , Rehab Ahmed Lotfy Saleh , Mona Morad Mohammed Ibrahim
246	1	5	_aدراسات عقاقير على نبات الجرد(ججيمنوكاربس ديكاندرس) النامى بالساحل الشمالى الغربى لمصر
260			_aCairo : _bMahmoud Mohammed Mubarek , _c2019
300			_a132 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aGymnocarpos decandrus Forssk., family Caryophyllaceae is a well-known grazing wild plant growing in the middle east region and north Africa. Recently several medicinal activities; anti-inflammatory, analgesic and diuretic were reported for G. decandrus.Forssk. The current investigation includes identification, authentication, phytochemical investigation and biological evaluation of G. aerial parts. The botanical study and DNA fingerprinting were performed for complete characterization, documentation as well as differentiation of G. decandrus Forssk. Moreover identification through the chemical constituents via HPLC/PDA/MS/MS that allowed for detection of 19 metabolites. Flavonoids were the major class of secondary metabolites. Application of various chromatographic and spectral techniques resulted in isolation and identification of 5,2' -Dihydroxy-7,8,6'- trimethoxyflavone (rivularin), vitexin, protocatechuic acid, quercetin, isorhamnetin and quercetin 3-O-Ý-D-glucopyranoside (isoquercetin) from G. decandrus Forssk. Moreover, criteria for standardization of G. decandrus Forssk. extract were established including determination of proximate composition and nutritive value as well as analysis of carbohydrate, lipids and amino acid components. The safety margin (LD50 and chronic toxicity), antidiabetic, Ü-Glucosidase inhibitory effect, Coxsackie B4 antiviral activity and cytotoxic effects of the plant ethanolic extract were assessed
530			_aIssued also as CD
653		4	_aBotanical features
653		4	_aDNA fingerprinting
653		4	_aGymnocarpos decandrus Forssk
700	0		_aMona Morad Mohammed Ibrahim , _eSupervisor
700	0		_aRehab Ahmed Lotfy Saleh , _eSupervisor
700	0		_aSeham Salah Eldin Elhawary , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c75168 _d75168