000			03047cam a2200349 a 4500
003			EG-GiCUC
005			20250223032507.0
008			191228s2019 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.04.M.Sc.2019.Om.R
100	0		_aOmnia Ashraf Saad Ali Elsawaby
245	1	0	_aRadiotherapeutic impact on cancerous cell radiosensitivity of silica-coated iron oxide nanoparticles / _cOmnia Ashraf Saad Ali Elsawaby ; Supervised Wael M. Elshemey , Heba Mohamed Fahmy , Mohamed Mahmoud Fathy
246	1	5	_aالتأثير العلاجى لجسيمات أكسيد الحديد النانوية المغلفة بالسيليكا علي الحساسية الإشعاعية للخلايا السرطانية
260			_aCairo : _bOmnia Ashraf Saad Ali Elsawaby , _c2019
300			_a86 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics
520			_aRadiation therapy (RT) is one of the most commonly used non-surgical interventions in cancer therapy. Due to reported radioresistance of many cancer cells, radiosensitizers are introduced to cancer cells as a tool to overcome such radioresistivity. There have been several attempts to use high-atomic number nanoparticles as radiosensitizer agents in cells. In this study, a novel nanoradiosensitizer composed of magnetic nanoparticle core coated with silica was successfully prepared and applied to overcome cancer radioresistance. The prepared nanoparticles were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS), atomic force microscopy (AFM) and vibration sample magnetometer (VSM). The radioenhancing effects of iron oxide magnetic nanoparticles (IO-MNPs) and silica-coated iron oxide magnetic nanoparticles (SIO-MNPs) were examined in breast cancer cells (MCF7) by MTT and comet assays. MCF7 cells were treated with different concentrations of the prepared nanoparticles and exposed to electron beam and X-ray photon beam at doses of 0, 0.5, 1, 2, 4 Gy. DLS diameters of IO-MNPs and SIO-MNPs were 18 ± 4.5 nm and 164 ± 16 nm, respectively. For electron beam, MCF7 cells treated with 5, 10, 20, 40 and 80 æg /ml of SIO-MNPs and exposed to 4 Gy showed dose enhancement factor (DEF) values of 1.03, 1.32, 1.29, 1.42 and 1.64 respectively. For X-ray beam, DEF values of cells treated with 20, 40 and 80 æg /ml of SIO-MNPs and exposed to 1 Gy were 1.43, 1.65 and 2.20 respectively
530			_aIssued also as CD
653		4	_aIron oxide magnetic nanoparticles (IO-MNPs)
653		4	_aMCF7 cell lines
653		4	_aSilica-coated iron oxide magnetic nanoparticles (SIO-M NPs)
700	0		_aHeba Mohamed Fahmy , _eSupervisor
700	0		_aMohamed Mahmoud Fathy , _eSupervisor
700	0		_aWael M. Elshemey , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c76127 _d76127