000			02915cam a2200349 a 4500
003			EG-GiCUC
005			20250223032511.0
008			200108s2019 ua do f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.07.M.Sc.2019.An.P
100	0		_aAnn Gamal Boulis Kirolos
245	1	2	_aA phytochemical and biological study of ulmus pumila L. cultivated in Egypt / _cAnn Gamal Boulis Kirolos ; Supervised Soheir M. Elzalabani , Farouk R. Melek , Omar M. Sabry
246	1	5	_aدراسة فيتوكيميائية و بيولوجية لنبات أولمس بوميلا ل. المزروع فى مصر
260			_aCairo : _bAnn Gamal Boulis Kirolos , _c2019
300			_a248 P. : _bcharts , photographs ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aUlmus pumila L., a member of family Ulmaceae, is successfully grown in Egypt. Genus Ulmus is renowned for its cytotoxic terpenoids. The current study aimed to investigate the locally cultivated plant as a potential source of cytotoxic constituents that could be employed in the pharmaceutical industries. Reports on either the phytoconstituents of the aforementioned species or its evidence-based biological activities were rare or completely lacking, thus granting a great interest in its intensive phytochemical and biological investigation. The methanol extracts of the stem bark and leafy branches of the investigated species were subjected to phytochemical screening, TLC investigation, and quantitative estimation of the major constituents. The composition of the lipoidal matter of both was examined via GC/MS analysis. The dichloromethane fraction of the methanol extract of the stem bark and the ethyl acetate fraction of the methanol extract of the leafy branches were selected for intensive phytochemical investigation based on available literature on genus Ulmus, TLC analysis of the various fractions, and total phenolic, flavonoid, and terpenoid/steroid contents of the total extracts. Repeated chromatographic fractionation of the dichloromethane fraction of the methanol extract of the stem bark yielded six isolates identified as Friedelin, 3Ý-acetoxyurs-11-en-13Ý,28-olide, 3Ý-O-acetyl ursolic acid contaminated with 3Ý-O-acetyl oleanolic acid, a mixture of Ý-Sitosterol and Stigmasterol, Betulinic acid, and a mixture of Methyl ursolate and Methyl oleanolate
530			_aIssued also as CD
653		4	_aCytotoxic Potential
653		4	_aLeafy Branches
653		4	_aLipoid Profiling
700	0		_aFarouk R. Melek , _eSupervisor
700	0		_aOmar M. Sabry , _eSupervisor
700	0		_aSoheir M. Elzalabani , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAsmaa _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c76247 _d76247