| 000 | 02715cam a2200337 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032525.0 | ||
| 008 | 200220s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.08.Ph.D.2020.Om.F | ||
| 100 | 0 | _aOmar Ali Abdalla Elkady | |
| 245 | 1 | 0 |
_aFormulation and characterization of promising carrier systems for pulmonary drug delivery / _cOmar Ali Abdalla Elkady ; Supervised Hanan M. Ellaithy , Mina Ibrahim Tadros |
| 246 | 1 | 5 | _aصياغة وتوصيف أنظمة حمل واعدة لتوصيل العقار رئويا |
| 260 |
_aCairo : _bOmar Ali Abdalla Elkady , _c2020 |
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| 300 |
_a131 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics | ||
| 520 | _aRisedronate sodium (RS) is a potent inhibitor of bone resorption; having an extreme poor permeability and limited oral bioavailability (0.62%). RS should be orally administered under fasting conditions, while keeping in an upright posture for at least 30 min, to diminish common gastroesophageal injuries. To surmount such limitations, novel Risedronate-chitosan (RS-CS) crosslinker-free nebulizable microspheres were developed adopting quality by design (QbD) approach and Risk assessment (RA) thinking. RS:CS ratio, surfactant (Pluronic® F127) concentration, homogenization duration, speed and temperature were identified using Ishikawa diagrams as the highest formulation- and process-risk factors affecting the critical quality attributes (CQAs); average particle size (PS) and entrapment efficiency (EE%). The risk factors were screened using Plackett-Burman design and the levels of the most significant factors were optimized using a multi-level factorial-design to explore the optimized system with the least PS, maximum EE% and a prolonged drug release profile. The optimized system (B6) was developed at RS:CS ratio of 1:7, a surfactant concentration of 2% (w/v) and a homogenization speed of 14000 rpm. It revealed well correlation with QbD theoretical prediction where, positively charged (47.9±3.39 mV) discrete, spherical microspheres (3.47±0.16 æm), having a high EE% (94.58±0.19%) and prolonged RS release over 12 hours (Q12h, 89.70±0.64%) were achieved | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aChitosan | |
| 653 | 4 | _aCrosslinker-free | |
| 653 | 4 | _aRisedronate sodium | |
| 700 | 0 |
_aHanan M. Ellaithy , _eSupervisor |
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| 700 | 0 |
_aMina Ibrahim Tadros , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAsmaa _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c76716 _d76716 |
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