000			02894cam a2200337 a 4500
003			EG-GiCUC
005			20250223032529.0
008			200229s2020 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2020.Ib.N
100	0		_aIbram Refat Boshra Mikhail
245	1	0	_aNew approaches for the synthesis of novel heterocyclic compounds derived from cyanomethylene and Ý-diketone compounds and determination of their biological effect / _cIbram Refat Boshra Mikhail ; Supervied Rafat Milad Mohareb , Noha M. H. Elnagdi
246	1	5	_aإتجاهات جديدة لتحضير مركبات جديدة غير متجانسة الحلقة مشتقة من مركبات السيانوميثيلين والبيتا ثنائى الكيتون وتعيين تأثيرها البيولوجى
260			_aCairo : _bIbram Refat Boshra Mikhail , _c2020
300			_a169 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aPyrazoles are an important heterocyclic family due to their wide spectrum of biological properties such as the anti-proliferative activities and inhibition toward tyrosine kinases. In the present work we started with pyrazole derivative (3) produced through the reaction of ethyl benzoylacetate (1) with hydrazine hydrate (2) followed by its heterocyclization to produce fused derivatives. The target compounds were synthesized in steps outlined in Schemes 1-6. The reaction of the pyrazole (3) with elemental sulfur and phenylisothiocyanate (4) gave the derivative (5). The molecular structure of compound (5) was confirmed on the basis of its elemental and spectral data. On the other hand, the reaction of compound (3) with ethyl orthoformate gave the 4-ethoxymethyleno derivative (6). The presence of the ketone and the active methylene moieties in compound (3) enhanced the synthesis of thieno[3,2-c]pyrazol derivatives using Gewald{u2019}s thiophene synthesis. Next, we moved towards the formation of some heterocyclic compounds starting from compound (3). The anti-proliferative activities of the newly synthesized compounds were evaluated against the six cancer cell lines. It is clear that compounds 8b, 9, 12b, 12d, 14b, 15b, 18d, 18f, 19b and 21d were the most active compounds. Several tests as Melting point, IR spectra, ¹H-NMR spectra, Mass spectra and analytical data (element analysis) have been made on all components
530			_aIssued also as CD
653		4	_aPyran
653		4	_aPyrazol derivatives
653		4	_aPyridine
700	0		_aNoha M. H. Elnagdi , _eSupervisor
700	0		_aRafat Milad Mohareb , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c76814 _d76814