| 000 | 03083cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032554.0 | ||
| 008 | 200908s2020 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.25.M.Sc.2020.Is.S | ||
| 100 | 0 | _aIsmail Mohamed Rafeky Hussien Saad | |
| 245 | 1 | 0 |
_aStudying HCV IRES sequence and structure for genotype 4a-in correlation to interferon ribavirin responding treatment in Egyptian patients using bioinformatics / _cIsmail Mohamed Rafeky Hussien Saad ; Supertvised Fawzy Ali Ataby , Salwa Farouk Sabet , Mohamed Ali Saber |
| 246 | 1 | 5 | _aدراسة المنطقه المسؤله عن الدخول الي الريبوسوم الداخلى فى فيروس التهاب الكبدى سى من حيث التسلسل النيكولتيدى و التركيب الثانوى للسلاله ( 4أ) و علاقه ذلك بالاستجابه لعلاج الانترفيرون\ريبافيرين فى حالات المرضى المصرين باستخدام المعلوماتية الحيوية |
| 260 |
_aCairo : _bIsmail Mohamed Rafeky Hussien Saad , _c2020 |
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| 300 |
_a113 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology | ||
| 520 | _aHepatitis C virus infection is the major cause of chronic hepatitis. The HCV genotype 4a is predominant in Egyptian patients that are not responding to the combined pegylated interferon-alpha /ribavirin therapy. The HCV IRES is a well-defined structure of about 341 nucleotides in its 5{u00B4}-untranslated region (UTR). This study was conducted on 46 Quantification of HCV-RNA in serum has been carried out at the beginning of treatment (W0) and at week12 (W12), patients 26 responders and 20 non-responders to Study HCV IRES Sequence and Secondary Structure and find the Correlation to pegylated Interferon\Ribavirin Responding Treatment in Egyptian patients. There was no statistically significant difference between Responders and Non-Responders regarding gender (P=0.1), age (p=0.3), AFP (p=0.4) and Albumin (p=0.1) while There was a significant increase for AST/ALT (p=0.002, p=0.001) respectively. HCV IRES RT-PCR and sequence analysis including genotyping, MSA and Sequence variation showed that 98% genotype 4a and there was no significant difference in sequence between Responders and Non-Responders patients in addition to the prediction of HCV IRES secondary structure MFE,Centroid revealed that there was no effect on IRES secondary structure and it is conserved among all HCV genotypes | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aGenotype 4a | |
| 653 | 4 | _aHepatitis C Virus (HCV) | |
| 653 | 4 | _aPolymerase Chain Reaction (qPCR) | |
| 700 | 0 |
_aFawzy Ali Ataby , _eSupervisor |
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| 700 | 0 |
_aMohamed Ali Saber , _eSupervisor |
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| 700 | 0 |
_aSalwa Farouk Sabet , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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_c77636 _d77636 |
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