000			03146cam a2200337 a 4500
003			EG-GiCUC
005			20250223032609.0
008			201005s2020 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.10.Ph.D.2020.Mo.S
100	0		_aMohamed Sayed Mohamed Mohamed Farghaly
245	1	0	_aSynthesis of some fused heterocycles from laboratory available starting materials / _cMohamed Sayed Mohamed Mohamed Farghaly ; Supervised Fathy Mohamed Abdelrazek , Sobhy Mohamed Gomaa
246	1	5	_aتحضير بعض الحلقيات غير متجانسة الملتحمة من بادئات متوافرة معمليا
260			_aCairo : _bMohamed Sayed Mohamed Mohamed Farghaly , _c2020
300			_a197 P. ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aA novel series of 1,5-dihydropyrido-triazolo-pyrimidine derivatives were prepared by cyclocondensation of 2-thioxo-pyrido[2,3-d]pyrimidines (prepared from reaction of chalcone with 6-aminothiouracil) with a variety of hydrazonoyl chlorides. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides (obtained from the reaction of ethyl 3-oxo-2-(2-arylhydrazono)butanoates with thiosemicarbazide) could be transformed into a variety of thiazolyl-pyrazole derivatives via their reaction with a diversity hydrazonoyl chlorides as well as bromoacetyl derivatives. Grinding a mixture of 6-aminopyrimidine-2,4-(1H, 3H)dione, 6-amino-2-thioxo-2,3- dihydropyrimidine-4(1H)-one or ethyl 7-amino-5-oxo-1-aryl-1,5-dihydro[1,2,4]-triazolo[4,3- a]pyrimidine-3-carboxylate derivatives with 1,2-diphenylethanone and different aromatic aldehydes in presence of aluminate sulfonic acid nanoparticles (ASA NPs) in a one pot solvent-free conditions, afforded the pyrido[2,3-d]pyrimidinone derivatives and ethyl 5-oxo- 1-aryl-6,7,8-triphenyl-1,5,6,9-tetrahydropyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-3- carboxylate derivatives respectively. All structures were elucidated by spectral and elemental analyses. Some structures were further proved by alternative synthesis. Some of the synthesized compounds are forced for molecular docking by using MOE 2014.010 Package software; one of in-silico study tools. These compounds are targeting Human Cyclin Defendant Kinase 2 (CK2) PDB ID (1PXO.Protein data bank) due to its important role in controlling of the human cell cycle and also for meiosis. Moreover, the computational studies were carried out for some new compounds.The results indicated that these compounds showed promising binding affinities against the active site of the epidermal growth factor receptor kinase (EGFR)
530			_aIssued also as CD
653		4	_aCyclocondensation
653		4	_aHydrazonoyl halides
653		4	_aPyrido[2,3-d]pyrimidine
700	0		_aFathy Mohamed Abdelrazek , _eSupervisor
700	0		_aSobhy Mohamed Gomaa , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c78084 _d78084