000			03371cam a2200349 a 4500
003			EG-GiCUC
005			20250223032611.0
008			201011s2020 ua dho f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.10.M.Sc.2020.Ha.T
100	0		_aHadeel Salim Ali Salman
245	1	0	_aTranexamic acid versus fractional CO2 laser in post-inflammatory hyperpigmentation in acne patients / _cHadeel Salim Ali Salman ; Supervised Shereen Osama Tawfic , Rania Mohamed Mounir , Maha Fathy Elmasry
246	1	5	_aدراسة مقارنة بين تأثير استخدام حمض الترانيكساميك و ليزر ثانى أكسيد الكربون التجزيئى فى علاج فرط التصبغ المصاحب لحب الشباب
260			_aCairo : _bHadeel Salim Ali Salman , _c2020
300			_a180 P. : _bcharts , facsimiles , photoghrphs ; _c30cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520			_aBackground:Acne is a commonly encountered disorder in the dermatological practice.Post-acne hyperpigmentation is a common undesirablesequalae of acne vulgaris that occurs at a young age and causes distress for many patients. Various treatment modalities have been tried for the post-acne hyperpigmentation including low power fractional CO2 laser and intradermal injections of tranexamic acid (TXA). Objective: This study aimed at investigating and comparing the efficacy of both low-power low-density fractional CO2 laser and intradermal injection of TXA on post- acne hyperpigmentation. Patients and methods:A total of twenty-five patients with bilateral, symmetrical post-acne hyperpigmentation on both cheeks were enrolled in this randomized comparative split face study.One side of the face was randomly assigned to low power fractional CO2 laser every four weeks for three months.The other side of the face was assigned to TXA intradermal microinjection every two weeks for three months. Efficacy was evaluated using digital photography, dermoscopy, the post acne hyperpigmentation index (PAHPI), melanin index (MI) and erythema index (EI) at baseline and two weeks after the last session. Patient satisfaction score was also assessed.Results: Both fractional CO2 laser and intradermal injection of TXA treatment sides showed significant reduction in the PAHPI and MI (p<0.001).Significant reduction in the total dermoscopic score was also noted on the side receiving fractional CO2 laser and the other side receiving intradermal injection of TXA(p<0.001). However, the EI showed non-significant difference on both sides.There was a statistically significant difference with better percentage of improvement regarding the total dermoscopic score on the side receiving fractional CO2 laser than the side receiving intradermal injection of TXA (p<0.009)
530			_aIssued also as CD
653		4	_aFractional CO2 laser
653		4	_aPost-acne hyperpigmentation
653		4	_aTranexamic acid (TXA)
700	0		_aMaha Fathy Elmasry , _eSupervisor
700	0		_aRania Mohamed Mounir , _eSupervisor
700	0		_aShereen Osama Tawfic , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c78163 _d78163