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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.12.10.Ph.D.2019.Es.G
100 0 _aEsraa Azmy Abdelwahab
245 1 0 _aGrafting of some heterocyclic compounds onto surface of carbon nanotubes /
_cEsraa Azmy Abdelwahab ; Supervised Nadia Hanafy Metwally , Gamal Riad Saad , Mahmoud Aly Elkomy
246 1 5 _aتطعيم بعض المركبات غير متجانسة الحلقة على سطح انابيب الكربون النانومترية
260 _aCairo :
_bEsraa Azmy Abdelwahab ,
_c2019
300 _a180 P . :
_bcharts , facsmilies ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520 _aPyrazole and pyrazolone derivatives were grafted onto the surface of carboxylated multiwalled carbon nanotubes (MWCNTs)via the reaction of carboxylated MWCNTs and the diazonium salts of pyrazoles and pyrazolones using mixed acid treatment. The insertion of the pyrazole and pyrazolone moieties was characterized by Fourier transform infrared (FT-IR) spectroscopy, energy dispersion spectroscopy, transmission electron microscopy, X-ray diffraction and thermogravimetric (TGA). The results indicate that pyrazole and pyrazolone moieties successfully attached on carboxylated MWCNTs surface. The neat pyrazole and pyrazolone derivatives and their corresponding CNTs were tested against Staphylococcus aureus, Bacillus subtilus, Escherichia coli, and Candida albicans bacteria,and Aspergillusniger fungi. The results showed that the grafted CNTs of pyrazole and pyrazolone derivatives have better antimicrobial activity than the neat pyrazole and pyrazolone derivatives. Also, the Zeta potential was carried out for the synthesized compounds, In addition to molecular docking was performed of the most potent antimicrobial compounds to investigate the existence of the interactions between the most active inhibitors and Farnesyl pyrophosphate synthase (FPPS)
530 _aIssued also as CD
653 4 _aAntimicrobial activity
653 4 _aCarbon nanotubes
653 4 _aZeta-potential and molecular docking study
700 0 _aGamal Riad Saad ,
_eSupervisor
700 0 _aMahmoud Aly Elkomy ,
_eSupervisor
700 0 _aNadia Hanafy Metwally ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAmira
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c78503
_d78503