000			03104cam a2200349 a 4500
003			EG-GiCUC
005			20250223032632.0
008			201121s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2019.Mo.R
100	0		_aMohamed Madboly Mohamed Soliman
245	1	0	_aRole of osteoprotegerin (OPG) level and its gene polymorphism in the pathogenesis of osteoporosis in thalassemia major / _cMohamed Madboly Mohamed Soliman ; Supervised Ilham Youssry Ibrahim , Rania Mohamed Samy , Dalia Salah Eldin Ahmed
246	1	5	_aدور مستوى الاستيوبروتيجرين فى الدم وتعدد جيناته فى الألية المرضية لمرض هشاشة العظام فى أنيميا البحر المتوسط
260			_aCairo : _bMohamed Madboly Mohamed Soliman , _c2019
300			_a172 P. : _bcharts , facimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Osteoporosis is a prominent cause of morbidity in patients with thalassemia major (TM) with a complex pathophysiology. Osteoprotegerin (OPG) and receptor activator of NF-kappa-B ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. Aims: To characterize the possible role of the OPG and its gene polymorphisms in the pathogenesis of osteoporosis in thalassemia major, as well as their relationship with bone mineral density (BMD). Patients and methods: In 60 Egyptian thalassemic patients and 60 healthy control children (age = 5-14 year), serum OPG measured by ELIZA and OPG single nucleotide polymorphisms (SNPs) (rs2073618 and rs2073617) detected by PCR-RFLP technique.The patients had recent results of BMD scanning using dual X-ray absorptiometry (DEXA). Results: High prevalence of bone diseases was detected in TM patients, 40% had spine low bone mass, 10% had femur low bone mass, 70% complained from bone pain, 8.3% had history of long bone fracture related to minor trauma, and one patient had osteoporosis.The thalassemic patients showed significantly lower serum levels of OPG (P=0.003) and OPG/RANKL ratio (P= < 0.0001) as compared with controls. We couldn{u2019}t demonstrate significant association between serum OPG levels and BMD. Concerning OPG SNP rs2073618 we found that the G allele (P = 0.006) and GC genotype (p = 0.001) occurred more frequently in thalassemic patients with femur low bone mass than those with femur BMD Z- score > -2. While there was no relation between OPG SNP rs2073617 and BMD at any site of measurements
530			_aIssued also as CD
653		4	_aOsteoporosis
653		4	_aOsteoprotegerin (OPG)
653		4	_aThalassemia major (TM)
700	0		_aDalia Salah Eldin Ahmed , _eSupervisor
700	0		_aIlham Youssry Ibrahim , _eSupervisor
700	0		_aRania Mohamed Samy , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c78862 _d78862