| 000 | 03036cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032637.0 | ||
| 008 | 201128s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.10.M.Sc.2020.As.S | ||
| 100 | 0 | _aAsmaa Mahmoud Mohamed | |
| 245 | 1 | 0 |
_aStudy of the level of tumor necrosis factor like weak inducer of apoptosis (TWEAK) in psoriasis, atopic dermatitis and healthy controls : _bA comparative study / _cAsmaa Mahmoud Mohamed ; Supervised Hanan Rabea Nada , Heba Ahmed Abdelkader , Laila Ahmed Rashed |
| 246 | 1 | 5 |
_aدراسة مستوى عامل نخر الورم محفز للإستماتة (تويك) فى مرض الصدفية والتهاب الجلد التأتبى ومقارنته فى الضابط : _bدراسة مقارنة |
| 260 |
_aCairo : _bAsmaa Mahmoud Mohamed , _c2020 |
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| 300 |
_a107 P. : _bcharts , facimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology | ||
| 520 | _aBackground: Psoriasis and atopic dermatitis (AD) are common, chronic, inflammatory, T-cell-mediated diseases. Both are multifactorial diseases with skin-barrier disruption, genetic, environmental and immunological factors contributing to their pathogenesis. Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) is a member of the TNF ligand superfamily. Previous studies suggested a role of TWEAK/Fn14 pathway in psoriasis and atopic dermatitis. However, studies are quite limited with some controversial results. Objective: To further elucidate the role of TWEAK in psoriasis and AD and to explore its relation with clinical variables of both diseases. Methods: A case control study was conducted on 90 subjects; 30 patients with psoriasis, 30 patients with atopic dermatitis and 30 age and sex matched healthy controls. Skin biopsies were obtained from the lesional skin of patients and normal skin of controls to determine the level of tissue TWEAK (pg/mg) by ELISA. Results: TWEAK level was significantly higher in patients with psoriasis or atopic dermatitis compared to controls. A statistically significant difference was found between the level of TWEAK in patients with psoriasis and those with AD, being higher in patients with psoriasis. TWEAK level showed a significant positive correlation with AD disease duration. Limitations: Limitations of this study are the exclusion of clinical types of psoriasis and AD, other than vulgaris type and adult AD, respectively and exclusion of paediatric patients | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAtopic dermatitis | |
| 653 | 4 | _aPsoriasis | |
| 653 | 4 | _aTWEAK | |
| 700 | 0 |
_aHanan Rabea Nada , _eSupervisor |
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| 700 | 0 |
_aHeba Ahmed Abdelkader , _eSupervisor |
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| 700 | 0 |
_aLaila Ahmed Rashed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c78988 _d78988 |
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