| 000 | 02515cam a2200325 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032645.0 | ||
| 008 | 201219s2020 ua f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.10.Ph.D.2020.Ma.S | ||
| 100 | 0 | _aMarwa Maher Abdelmohsen Bayoumi | |
| 245 | 1 | 0 |
_aSynthesis of some new heterocyclic compounds from nitrile derivatives / _cMarwa Maher Abdel Mohsen Bayoumi ; Supervised Sanaa Osman Abdallah |
| 246 | 1 | 5 | _aتشييد بعض المركبات غير المتجانسة الحلقة الجديدة من مشتقات النيترين |
| 260 |
_aCairo : _bMarwa Maher Abdel Mohsen Bayoumi , _c2020 |
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| 300 |
_a222 P. ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry | ||
| 520 | _aThe starting N,N-bis(cyanoacetyl)hydrazine 3 was prepared by the reaction of cyanoacetic acid hydrazide 1 and 3-(3 ,5-dimethyl-1H-pyrazol-1-yl)-3- oxopropanenitrile 2. Condensation of compound 3 with each of aromatic aldehydes 4a-k, o-hydroxybenzaldehydes 8a,b and azosalicylaldehydes 12a-e under grind stone method afforded the respective arylmethylene derivatives Sak, his-coumarin derivatives lla,b and 15a-e, respectively. Coupling of 3 with aryldiazonium chlorides gave arylhydrazono derivatives 17a-e. Also , antimicrobial activity for some new products, enzyme inhibition and agarose gel electrophoresis were investigated. Next, malononitrile considered as the starting material to prepare 5-amino-3- (cyanomethyl)-1-phenyl-lH-pyrazole-4-carbonitrile 20. Acid hydrolysis of compound 20 gave 3-amino-2-phenyl-2,7-dihydro-4H-pyrazolo[ 4,3-c ]pyridine- 4,6(5H)-dione 39. Condensation of each of 20 and 39 with various aromatic aldehydes afforded the corresponding arylmethylenes 23a-i and 40a-I, respectively. Coupling of 39 with aryldiazonium chlorides led to formation of arylhydrazono derivatives 53a-e.Moroever, acetylation of 39 yielded the Nacetyl derivative 43. The anticancer activity of some of the newly synthesized compounds was investigated. Also, molecular docking study was performed | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAntimicrobial activity | |
| 653 | 4 | _aBis-coumarins | |
| 653 | 4 | _aN,N-bis( cyanoacetyl)hydrazine | |
| 700 | 0 |
_aSanaa Osman Abdallah , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c79264 _d79264 |
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