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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.10.M.Sc.2020.Di.C
100 0 _aDina Ibrahim Abdullah Aboalazm
245 1 0 _aComparing tranexamic acid microinjection alone versus its combination with fractional CO2 laser in melasma treatment /
_cDina Ibrahim Abdullah Aboalazm ; Supervised Shereen Osama Tawfic , Rania Mohamed Mounir , Eman Raafat Abdelfattah
246 1 5 _aمقارنة بين استخدام حمض الترانيكساميك فقط أو استخدامه مع ليزر ثانى أكسيد الكربون فى علاج الكلف
260 _aCairo :
_bDina Ibrahim Abdullah Aboalazm ,
_c2020
300 _a145 P. :
_bcharts , facimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520 _aBackground: Melasma is a challenging hypermelanotic disorder, which is difficult to treat. Different modalities of laser therapy have been tried for the treatment of melasma such as fractional CO2 laser. Tranexamic acid (TXA) has been suggested as an effective treatment for melasma, with promising results. Objective: The aim of this study isto assess and comparethe efficacy of tranexamic acid intradermal microinjection alone versus its combination with low power low-density fractional CO2 laser in a sequential pattern. Methods: A total of twenty-nine patients with bilateral, symmetrical melasma were enrolled in this randomized comparative split face study. One side of the face was randomly assigned to low power low-density fractional CO2 laser, while other side to TXA intradermal microinjection on 1st session. This split face session was repeated every six weeks for 3 sessions. In addition, TXA was applied by microinjection for full face every two weeks in between the split face sessions in sequential pattern.The treatment duration was 4 months. Efficacy was evaluated using digital photography, dermoscopy, melanin index (M.I) and erythema index (E.I) at baseline and four weeks after the last session. Patient satisfaction score was also assessed
530 _aIssued also as CD
653 4 _aFractional CO2 laser
653 4 _aMelasma
653 4 _aTranexamic acid
700 0 _aEman Raafat Abdelfattah ,
_eSupervisor
700 0 _aRania Mohamed Mounir ,
_eSupervisor
700 0 _aShereen Osama Tawfic ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c79384
_d79384