000			02849cam a2200349 a 4500
003			EG-GiCUC
005			20250223032653.0
008			210110s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.10.M.Sc.2020.Em.A
100	0		_aEman Assaad Hamed Ibrahim
245	1	0	_aAssessment of the level of serum and tissue Coenzyme q10 in Pemphigus Vulgaris patients versus controls : _bA case control study / _cEman Assaad Hamed Ibrahim ; Supervised Marwah Adly Mohamed Saleh , Heba Ahmed Mohamed Ahmed Abdelkader , Laila Ahmed Rashed
246	1	5	_aدراسة الحالات والشواهد : _bتقييم مستوى الإنزيم المساعد كيو 10 فى مصل الدم والأنسجة فى مرضى ذو الفقاع الشائع مقارنة بالأصحاء
260			_aCairo : _bEman Assaad Hamed Ibrahim , _c2020
300			_a96 P. : _bcharts , facsmilies ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Dermatology and Venerology
520			_aBackground: Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease of the skin and mucous membranes. It occurs due to the action of autoantibodies against various keratinocyte self-antigens. Antimitochondrial autoantibodies were detected in PV. Coenzyme Q10 (CoQ10) is a member of the mitochondrial respiratory chain that is involved in cellular metabolism including apoptosis. Objective: to assess the level of CoQ10, both in serum and tissue, in PV patients versus healthy controls to determine its relevance to the pathogenesis of the disease. Methods: A case control study included twenty patients with pemphigus vulgaris and twenty age- and sex-matched controls. Blood and skin samples were collected for the measurement of CoQ10 level by ELISA. Results: CoQ10 was significantly lower both in serum and tissue of PV patients compared to controls (p=0.001). Similar results were found when gender subgroups were compared separately. A significant positive correlation was found between serum and tissue CoQ10 levels in controls but not in PV patients (p=0.019, r=0.521). Conclusion: CoQ10 appears to be one of the victims of the autoimmune response in PV, adding to the tissue damage caused by autoantibodies. CoQ10 supplementation might be of value in the treatment of PV
530			_aIssued also as CD
653		4	_aDesmoglein1
653		4	_ahuman leucocyte antigen
653		4	_aPemphigus vulgaris
700	0		_aHeba Ahmed Mohamed Ahmed Abdelkader, _eSupervisor
700	0		_aLaila Ahmed Rashed , _eSupervisor
700	0		_aMarwah Adly Mohamed Saleh , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c79510 _d79510