000			03341cam a2200337 a 4500
003			EG-GiCUC
005			20250223032718.0
008			210321s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.07.04.Ph.D.2020.Sh.C
100	0		_aShaimaa Sayed Taha Shoman
245	1	0	_aCorrelation between antioxidant activity, cytotoxicity and silver nanoparticles synthesis of some egyptian plants / _cShaimaa Sayed Taha Shoman ; Supervised Mohye Eldein Ali Osman , Ghada Ibrahim Mahmoud
246	1	5	_aالإرتباط بين النشاط المضاد للأكسدة والسمية الخلوية وتخليق جزيئات الفضة النانونية لبعض النباتات المصرية
260			_aCairo : _bShaimaa Sayed Taha Shoman , _c2020
300			_a208 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Agriculture - Department of Agricultural Biochemistry
520			_aPlants are commonly used in traditional medicines against number of diseases according to its cytotoxic effect. Therefore, studying the relation between antioxidant activity and cytotoxicity is remaining interesting to find a simple indicator for plant cytotoxicity. Moreover, the nanoparticle of bio molecules in plants can acts as capping and reducing agents and they have investigated in order to find an eco-friendly technique for production of well characterized effective nanoparticles. The objective of this study aimed to give the scientific evidence of the correlation between antioxidant activity and cytotoxicity in 11 different Egyptian plants and study the effect of nanotechnology technique on the biological activity of the most promising plants which have the ability to synthesis of silver nanoparticles. Phytochemical screening of 70% ethanolic extracts (EEs) has shown to be rich in steroids, terpenoids, flavonoids, tannins and phenols. The antioxidant activity of EEs gave inhibitory concentration of IC50 ranged between 42.33 (Ipomoea batatas leaves) and 1,519.76 og/ml (Citrullus colocynthis fruits) by DPPH method. The antioxidant activity of EEs gave inhibitory concentration of IC50 ranged between 31.60 (Avicennia marina leaves) and 1,133.79 og/ml (Cichorium endivia L. leaves) by ABTS method. The total phenolic content of EEs were ranged between 8.72 ± 0.08 (Daucus carota L. seeds) and 91.67 ± 0.13 (Avicennia marina leaves) as mg GAE/g dried sample. The Pearson's correlation coefficient (r) between antioxidant activity (IC50) as related to total phenolic content was strongly correlated, moderately correlated with brine shrimp cytotoxicity, weakly correlated with carcinogenic liver and breast cells cytotoxicity and weakly or no correlation with antimicrobial activity. These results proved that the total phenolic content could be indicator to the antioxidant scavenging activity but not the cytotoxic effect
530			_aIssued also as CD
653		4	_aAnticancer
653		4	_aAntimicrobial
653		4	_aAntioxidant
700	0		_aGhada Ibrahim Mahmoud , _eSupervisor
700	0		_aMohye Eldein Ali Osman , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80315 _d80315