000			03309cam a2200337 a 4500
003			EG-GiCUC
005			20250223032720.0
008			210327s2020 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2020.Sh.A
100	0		_aShimaa Anter Mahmoud
245	1	0	_aAnti-neoplastic activity of holothuria arenicola saponin against erlich ascites carcinoma in swiss albino mice / _cShimaa Anter Mahmoud ; Supervised Amel Mahmoud Soliman , Ayman Saber Mohamed
246	1	5	_aالنشاط المضاد للأورام لصابونين الهولوثوريا أينيكولا ضد سرطان إيرلش الإستسقائى فى الفئران البيضاء السويسرية
260			_aCairo : _bShimaa Anter Mahmoud , _c2020
300			_a118 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aCancer is a complex disease including various changes in cell physiology, which may lead to malignant tumors. The Ehrlich tumor is a quickly developing carcinoma with aggressive behavior. Saponins are important bioactive compounds in sea cucumbers that have an antioxidant, anti-microbial, anti-inflammatory, antiproliferative, and anti-tumor effect. The present investigation attempted to study the potential use of the Holothuria arenicola saponin (HaS) against Ehrlich Ascites Carcinoma (EAC) tumor model in female Swiss albino mice. Forty female Swiss albino mice were divided into four main groups (10 mice/group). Control, EAC, 5-fluorouracil (5-FU) and HaS treated groups. Control group daily injected intraperitoneally with 0.2 ml physiological saline from 0th day till the end of the experiment (10th day). Rest groups were inoculated with EAC cells (5 {u00D7} 10⁶ cells/mouse i.p.) at 0th day. Mice injected intraperitoneally with, 0.2 ml physiological saline (EAC), 5-FU (20 mg/kg) (5- FU) and saponin (120 mg/kg) (HaS) for 9 consecutive days. The HPLC studies of the extracted saponin showed the peak at retention time 5.19 min. was matched with the standard saponin with a total amount of 34.87%. HaS group showed a reduction in the Erlich ascetic volume (EAV), tumor cell count, the viability of tumor cells, and the activities of arginase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and creatinine, urea, uric, white blood cells (WBCs) and malondialdehyde (MDA).While it caused a general increase in the levels of hemoglobin (Hb), red blood cells (RBCs), platelets (Plt) and the activities of glutathione-S-transferase (GST), catalase (CAT) and glutathione reduced (GSH).The histopathological investigation showed clear improvement in the hepatic and kidney architecture. The results of this study clearly investigated that HaS is a potent natural product that has promising antineoplastic efficacy
530			_aIssued also as CD
653		4	_aHolothuria arenicola
653		4	_aSaponin
653		4	_aSea cucumber
700	0		_aAmel Mahmoud Soliman , _eSupervisor
700	0		_aAyman Saber Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80379 _d80379