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_aEG-GiCUC _beng _cEG-GiCUC |
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| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.09.M.Sc.2021.Me.P | ||
| 100 | 0 | _aMerhan Ossama Abdelghany Hindam | |
| 245 | 1 | 0 |
_aPossible neuroprotective effects of the coumarins : _bXanthotoxin and umbelliferone in the model of streptozotocin-induced sporadic Alzheimer{u2019}s disease in rats / _cMerhan Ossama Abdelghany Hindam ; Supervised Nesrine S. Elsayed , Rabab Hamed Sayed |
| 246 | 1 | 5 |
_aزانثوتوكسين و امبيلليفرون في النموذج المحدث به مرض الزهايمر المنتشر بفعل استربتوزوتوسين في الجرذان : _bالتأثيرات الممكنة الوقائية للأعصاب لكومارينز |
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_aCairo : _bMerhan Ossama Abdelghany Hindam , _c2021 |
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| 300 |
_a148 P . : _bcharts , facsmilies ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aThe aim of the present study was to assess the neuroprotective effects of xanthotoxin and umbelliferone in streptozotocin (STZ)-induced cognitive dysfunction in rats. Animals were injected intracerebroventricularly (ICV) with STZ (3 mg/kg) once to induce a sporadic Alzheimer's disease (SAD)-like condition. Xanthotoxin or umbelliferone (15 mg/kg, i.p.) were administered 5 hr after ICV-STZ and daily for 20 consecutive days. Xanthotoxin or umbelliferone prevented cognitive deficits in the Morris water maze and object recognition tests. In parallel, xanthotoxin or umbelliferone reduced hippocampal acetylcholinestrase activity and malondialdehyde level. Moreover, xanthotoxin or umbelliferone increased glutathione content. These coumarins also modulated neuronal cell death by reducing the level of proinflammatory cytokines) tumour necrosis factor-alpha and interleukin-6), inhibiting the overexpression of inflammatory markers (nuclear factor mB [NF-mB] and cyclooxygenase II), and upregulating the expression of NF-mB inhibitor (ImB-Ü). Interestingly, xanthotoxin diminished phosphorylated JAK2 and phosphorylated STAT3 protein expression, while umbelliferone markedly replenished nuclear factor erythroid-derived 2-like 2 (Nrf2) and haem oxygenase-1 (HO-1) levels. The current study provides evidence for the protective effect of xanthotoxin and umbelliferone in STZ-induced cognitive dysfunction in rats. This effect may be attributed, at least in part, to inhibiting acetylcholinestrase and attenuating oxidative stress, neuroinflammation and neuronal loss. | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAlzheimer's disease | |
| 653 | 4 | _aUmbelliferone | |
| 653 | 4 | _aXanthotoxin | |
| 700 | 0 |
_aNesrine S. Elsayed , _eSupervisor |
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| 700 | 0 |
_aRabab Hamed Sayed , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aAmira _eCataloger |
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_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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_c80650 _d80650 |
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