000			02254cam a2200349 a 4500
003			EG-GiCUC
005			20250223032733.0
008			210428s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.04.M.Sc.2020.Sa.D
100	0		_aSara Yahia Eweda Awad
245	1	0	_aDesign and synthesis of pyrazole derivatives with potential anticancer activity / _cSara Yahia Eweda Awad ; Supervised Aliaa Mohamed Kamal , Mohamed Kamal Abdelhamid , Amr Sayed Motawi Sonousi
246	1	5	_aتصميم وتشييد مشتقات البيرازول كمضادات للاورام
260			_aCairo : _bSara Yahia Eweda Awad , _c2020
300			_a153 P . : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Organic Pharmacy
520			_aThe present thesis comprises four chapters. The first chapter is an introduction which comprises the syntheses of pyrazolo[3,4-d]pyrimidine derivatives and the anticancer activity of some reported pyrazolopyrimidine derivatives. The second chapter demonstrates the aim of the work, along with the schemes that had been carried out to obtain new pyrazolopyrimidine derivatives. The third chapter explains the theoretical discussion of the experimental work along with the anticancer activity of all the synthesized compounds and the results of the cytotoxic activity. The fourth chapter consists of the experimental part of this work including the detailed procedures used for the synthesis of target compounds. In addition, the physical properties of the synthesized compounds, their elemental analyses and their spectral data are illustrated. Finally, the docking steps and the docking scores of all the compounds are shown
530			_aIssued also as CD
653		4	_aAnticancer activity
653		4	_ap38Ü inhibitors
653		4	_aPyrazolopyrimidines
700	0		_aAliaa Mohamed Kamal , _eSupervisor
700	0		_aAmr Sayed Motawi Sonousi , _eSupervisor
700	0		_aMohamed Kamal Abdelhamid , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c80796 _d80796