| 000 | 02687cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032802.0 | ||
| 008 | 210815s2021 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.28.M.Sc.2021.Sh.M | ||
| 100 | 0 | _aShareef Karam Ali Easa | |
| 245 | 1 | 0 |
_aMetformin as fetal hemoglobin inducer in non-transfusion-dependent thalassemia patients / _cShareef Karam Ali Easa ; Supervised Mona Hassan Eltagui , Mona Kamal Elghamrawy , Mariam Saad Soliman |
| 246 | 1 | 5 | _aميتفورمين" كمحفز للهيموغلوبين الجنينى فى مرضى أنيميا البحر الأبيض المتوسط غير المعتمدين على نقل الدم |
| 260 |
_aCairo : _bShareef Karam Ali Easa , _c2021 |
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| 300 |
_a103 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aBackground: Metformin was reported as a potential fetal hemoglobin (HbF) inducing agent but its efficacy and safety in Non-Transfusion-Dependent Thalassemia (NTDT) patients were not fully studied. Objectives: A prospective interventional study aimed to study the effect of metformin on HbF change in NTDT and its role in ameliorating disease severity. Methods: Forty-two patients with established diagnosis of NTDT aged 12-23 years old were enrolled. They were receiving a stable dose of Hydroxyurea (HU) over the last 3 months. Inclusion criteria:- Confirmed diagnosis of NTDT based on hemoglobin Electrophoresis and/or high performance liquid Chromatography .- Age greater than or equal to 12 years of age.- Stable dose of HU over the last 3 months.- Serum creatinine less than or equals to 1.4 mg/dl . - Liver enzymes (ALT and AST) less than or equal to 3 times upper limits of normal .- Patients/ parents giving willingly informed consents Exclusion Criteria: - Simple or chronic red blood cell transfusion therapy in the last 3 months.- Patients with diabetes mellitus who are receiving other anti-diabetic medications.- Patients with chronic hypoxemic conditions associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary diseases | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aHbF inducers | |
| 653 | 4 | _aMetformin | |
| 653 | 4 | _aNon-transfusion dependent Thalassemia | |
| 700 | 0 |
_aMariam Saad Soliman , _eSupervisor |
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| 700 | 0 |
_aMona Hassan Eltagui , _eSupervisor |
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| 700 | 0 |
_aMona Kamal Elghamrawy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c81729 _d81729 |
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