| 000 | 02564cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032814.0 | ||
| 008 | 210913s2021 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.19.02.Ph.D.2021.Ma.G | ||
| 100 | 0 | _aMai Mohamed Elsayed Lotfy | |
| 245 | 1 | 0 |
_aGenetic profiling of cell free circulating tumor DNA in breast cancer patients / _cMai Mohamed Elsayed Lotfy ; Supervised Abd Elrahman N. Zekri , Amany Abd Elhameed Aboubakr , Zeinab Korany M. Hassan |
| 246 | 1 | 5 | _aالنمط الجيني للحمض النووي الديوكسي ريبوسي المتحرر من خلايا مرضى سرطان الثدي |
| 260 |
_aCairo : _bMai Mohamed Elsayed Lotfy , _c2021 |
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| 300 |
_a138 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology | ||
| 520 | _adetected pathogenic variants (PVs) and likely pathogenic variants (LPVs). These genes were found to be involved in DNA repair mechanisms and WNT/Ý-catenin signalling pathways that will ultimately lead to cancer development. Also, it was revealed that 27.2% of the tissue-derived PVs/LPVs could be detected in ctDNAs, and 35.7% of ctDNA-derived PVs/LPVs could be found in paired tissues. The overall concordance rates for all of the identified somatic variants, PVs/LPVs only and genes carrying PVs/LPVs between both assays across all patients are 85.48%, 82.46% and 76.10%, respectively. According to their Cohen{u2019}s Kappa values, they have a statistically significant slight to fair agreement in both biopsies. While, the positive concordance rates for all of the identified somatic variants, PVs/LPVs only and the genes carrying PVs/LPVs in both assays across all patients are 28.77%, 7.79% and 11.56%, respectively. The level of agreement between the 2 assays -confined to the presence of concordant variants only- was represented by the negative values of Cohen{u2019}s Kappa which implies a statistically significant disagreement between the two platforms | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBreast cancer patients | |
| 653 | 4 | _aCirculating tumor | |
| 653 | 4 | _aDNA | |
| 700 | 0 |
_aAbdelrahman Nabawy Zekri , _eSupervisor |
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| 700 | 0 |
_aAmany Abdelhhameed Aboubakr , _eSupervisor |
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| 700 | 0 |
_aZeinab Korany M. Hassan , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c82104 _d82104 |
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