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003			EG-GiCUC
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008			211009s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2021.Ta.U
100	0		_aTasneem Mahmoud Halaby Shahat
245	1	0	_aUrinary transferrin as a bio-marker for early detection of nephropathy in type 2 diabetic Egyptian patients / _cTasneem Mahmoud Halaby Shahat ; Supervised Diaa Eldeen Abdelaziz Mohammed , Laila Ahmed Rashed , Noha Adly Sadik
246	1	5	_aدور الترانسفرين البولى فى الكشف المبكرعن اعتلال الكلى فى المرضى المصريين حديثى الإصابة ب النوع الثانى من داء السكرى
260			_aCairo : _bTasneem Mahmoud Halaby Shahat , _c2021
300			_a152 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aBackground:- Diabetic kidney disease (DKD) is one of the most important leading causes of chronic kidney disease and ESKD, albuminuria is still considered the earliest marker of DKD and because of its limited sensitivity and specificity, additional sensitive biomarkers are needed to detect DKD early and more accurately.Aim:-This study was carried out to: - Determine whether urinary transferrin can serve as an indicator of diabetic nephropathy.- To compare transferrinuria with albumiunuria as abiomarker of nephropathy in type 2 diabetes. Methods: - Our study included 60 type 2 diabetic patients younger than 60 years old, with diabetes duration around 5 years and 60 controls. All of them subjected to thorough history taking, clinical examination fundus examination, and the following Laboratory tests: Fasting blood glucose, 2h post prandial blood glucose, HbA1C, lipid profile, uric acid, urinary albumin/creatinine ratio and urinary transferrin.The patients were classified into three groups: normoalbuminuric (albumin excretion up to 30 mg/d) microalbuminuric (albumin excretion from 30{u2013}300 mg/d), and macroalbuminuric (albumin excretion >300 mg/d) and compared to the level of urinary transferrin and both (urinary transferrin and A/C ratio) as a markers of nephropathy were compared and correlated with all other parameters. Results:-Urinary transferrin level was significantly higher in patients compared to controls, the mean value of Urinary transferrin within patient group was 6.77±2.84 ng/ml and within control was 1.78±0.61 ng/ml and there was a statistically significant correlation in the urinary transferrin concentration in both microalbuminuric and macroalbuminuric groups with no significant relation in the normoalbuminuric group with a significant P value (0.017)
530			_aIssued also as CD
653		4	_aDiabetes Mellitus
653		4	_aDiabetic nephropathy
653		4	_aNephropathy biomarkers and urinary transferrin
700	0		_aDiaa Eldeen Abdelaziz Mohammed , _eSupervisor
700	0		_aLaila Ahmed Rashed , _eSupervisor
700	0		_aNoha Adly Sadik , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c82496 _d82496