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008			211108s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.02.Ph.D.2021.Ay.B
100	0		_aAya Abdelaziz Hanafey Mahmoud
245	1	0	_aBiochemical and molecular effects of some plant extracts on streptozotocin induced diabetic rats / _cAya Abdelaziz Hanafey Mahmoud ; Supervised Mohamed Ali Eldesouky , Doaa Samir Salah Eldin , Khairy Abdelmoneim Ibrahim
246	1	5	_aالتأثيرات الكيميائية الحيوية والجزيئية لبعض مستخلصات النباتات على الجرذان المصابة بمرض السكرى المستحث بالستربتوزوتوسين
260			_aCairo : _bAya Abdelaziz Hanafey Mahmoud , _c2021
300			_a144 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
520			_aStudy objective: The aim of the study is to assess the effect of aqueous extract of Pterocarpus santalinus heart wood and Brassica nigra seeds on amelioration of type 2 diabetes mellitus and evaluate the roles of these extracts on recover of diabetic nephropathy and diabetic liver injury in streptozotocin induced diabetic rats. The study is include 24 adult male albino rats and were divided into four groups, each group contain 6 animals. Group 1 served as control group. For induction of diabetes rats were received STZ (65 mg/kg body weight). After STZ induction the remaining three groups were split as follow: group 2 served as diabetic untreated group, group 3 served as diabetic group treated with aqueous Pterocarpus santalinus extract and group 4 served as diabetic group treated with aqueous Brassica nigra extract. Results: STZ administration produced significant up-regulation in the mRNA of Thioredoxininteracting protein (TXNIP), The Nod-like receptor protein 3(NLRP3) inflammasome and Apoptosis-enhancing nuclease (AEN). Also STZ administration produced significant increase in serum glucose, HbA1c, Homeostatic Model Assessment insulin resistance (HOMA-IR), lipids, creatinine, urea, ALT and AST levels; also, significant decrease in insulin, Homeostatic Model Assessment insulin sensitivity (HOMA-IS), Quantitative Insulin Sensitivity Check Index (QUICKI) and HDL levels. The effects of aqueous extracts of pterocarpus santalinus wood and Brassica nigra seeds were significant down-regulated the mRNA of TXNIP, NLRP3 and AEN. Also the results of this study showed that after treatment by aqueous of Pterocarpus santalinus wood and Brassica nigra seeds there were significant decreased in serum levels of glucose, HbA1c, lipids, creatinine, urea, ALT and AST as well as significant increase in insulin, Homeostatic Model Assessment insulin sensitivity (HOMA-IS), Quantitative Insulin Sensitivity Check Index (QUICKI) and HDL levels
530			_aIssued also as CD
653		4	_aBrassica nigra seeds
653		4	_aPterocarpus santalinus heart wood
653		4	_aType 2 diabetes mellitus
700	0		_aDoaa Samir Salah Eldin , _eSupervisor
700	0		_aKhairy Abdelmoneim Ibrahim , _eSupervisor
700	0		_aMohamed Ali Eldesouky , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c83043 _d83043