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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.28.M.Sc.2021.Sa.R
100 0 _aSara Ibrahim Ahmed Nassar
245 1 0 _aRole of MRI brain in diagnosis of children with organic acidemia /
_cSara Ibrahim Ahmed Nassar ; Supervised Mohamed Farouk Mohamed , Mona Ahmed Kamel Mohamed , Hadeel Mohamed Seif Elden
246 1 5 _aدور تصوير الدماغ بالرنين المغناطيسى فى تشخيص الأطفال المصابين بحمض عضوى
260 _aCairo :
_bSara Ibrahim Ahmed Nassar ,
_c2021
300 _a95 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520 _aIntroduction: organic acidemias (OAs) are group of metabolic disorders with enzymatic deficiency leading to accumulation of organic acids which has several neurological complications. Magnetic resonance imaging (MRI) of the brain can help in diagnosis of these neurological abnormalities before starting treatment for better outcome. Aim of the work: to evaluate the role of MRI brain in illustrating neurological changes in children with different types of organic acidemias and their diagnosis. Patients and methods: This cross-sectionaldescriptive study was performed on 42 children diagnosed to have organic acidemias and were following up at Pediatrics Hospitals, Cairo University, data from files were obtained including history related to disease, consanguinity, age of onset, clinical manifestations, examination including neurological examination and investigations including, routine laboratory investigations, tandem mass spectroscopy (TMS), other different investigations and MRI brain. Results: Glutaric acidemia I (61.9%) was the mostprevalent OA in our study. Fever and vomiting were more common with propionic acidemiawhile global developmental delay (GDD) was more commonly associated with glutaric acidemia I. Abnormal signals in globus pallidus was commonlydetected in isovaleric acidemia, encephalomalacia was commonlydetected in D2 hydroxy glutaric acidemia and pyroglutamic acidemia.Abnormal signal in basal ganglion was commonly detectedin propionic acidemia and glutaric acidemia I, 3-hydroxy glutaric acidemia. Conclusion: MRI brain had a key role in illustrating neurological changes in children with different types of organic acidemias and their diagnosis
530 _aIssued also as CD
653 4 _aGlobus pallidus
653 4 _aMRI
653 4 _aOrganic acidemia
700 0 _aHadeel Mohamed Seif Elden,
_eSupervisor
700 0 _aMohamed Farouk Mohamed ,
_eSupervisor
700 0 _aMona Ahmed Kamel Mohamed ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c83728
_d83728