000			02950cam a2200349 a 4500
003			EG-GiCUC
005			20250223032910.0
008			220109s2021 ua do f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.07.Ph.D.2021.Em.C
100	0		_aEman Hussein Reda Mahmoud
245	1	4	_aA comparative chemical and biological investigation of selected species from the genus centaurea growing in Egypt / _cEman Hussein Reda Mahmoud ; Supervised Elsayeda A. Elkashoury , Ali M. El Halwany , Khaled A. Shams
246	1	5	_aفحص كيميائى وبيولوجى مقارن لأنواع مختارة من جنس السنتاوريا الذى ينمو فى مصر
260			_aCairo : _bEman Hussein Reda Mahmoud , _c2021
300			_a271 P . : _bcharts , photographes ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aCentaurea genus is one of the largest genera of family Asteraceae consisting of 500-600 species. It is centered in the Mediterranean region and western Asia. Around 17 species of Centaurea are growing in Egypt. Reviewing the available literature on these species, there were no previous reports regarding C. pumilio. Few studies were found on C. eryngioides, C. alexandrina, C. calcitrapa, C. glomerata, C. scoparia, C. pallescens and C. lippii. A comparative chemical and biological study of the selected Centaurea species were carried out. Preliminary phytochemical screening was performed. The genetic diversity and genetic relationships between the 8 Centaurea species were investigated. Essential oil of selected Centaurea species was obtained by two different techniques, conventional hydrodistillation (HD) and microwave assisted extraction (MAE). Potential essential oil inhibitors of gyrase B enzyme and N-myristoyltransferase via an in silico molecular docking were screened to study the antibacterial activity. Gas chromatography-mass spectrometry analysis (GC-MS) of the essential oils obtained by both techniques was carried out. PCA (Principal component analysis) and AHC (Agglomerative hierarchical cluster) were used for categorization of essential oil samples. The in vitro antimicrobial activity for all essential oils was investigated against Staphylococcus aureus, Escherichia coli and Aspergillus niger. The biological activity of these Centaurea species was evaluated using sensitive and multidrug-resistant cancer cell lines
530			_aIssued also as CD
653		4	_aC. alexandrina
653		4	_aC. eryngioides
653		4	_aCentaurea pumilio
700	0		_aAli Mahmoud Elhalwany , _eSupervisor
700	0		_aElsayeda Ahmed Elkashoury , _eSupervisor
700	0		_aKhaled Ahmed Shams , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c83910 _d83910