000			02894cam a2200337 a 4500
003			EG-GiCUC
005			20250223032911.0
008			220110s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.09.M.Sc.2021.Mo.P
100	0		_aMohamed Ahmed Mahmoud Salem
245	1	0	_aPossible modulatory effect of tadalafil and bergapten on experimentally induced cognitive impairment in mice / _cMohamed Ahmed Mahmoud Salem ; Supervised Nesrine Salah Eldine Elsayed , Suzan Mohamed Mansour
246	1	5	_aتأثير فاعلية التطبيع المحتمل لعقارى التادالافيل والبيرجابتين لاعتلال الادراك المستحدث تجريبيا فى الفئران
260			_aCairo : _bMohamed Ahmed Mahmoud Salem , _c2021
300			_a139 P . : _bcharts , facsmilies ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Toxicology and Biochemistry
520			_aSporadic Alzheimer{u2019}s disease (SAD) is a slowly progressive neurodegenerative disorder characterized by deposition of amyloid beta (AÝ) plaques, tau protein aggregation, impaired insulin signaling, and neuroinflammation. This study aimed to investigate the neuroprotective potential of tadalafil (TAD) and bergapten (BG) in SAD-induced cognitive impairment in mice. SAD was induced by a single intracerebroventricular injection of streptozotocin (STZ) (3 mg/kg). TAD or BG was administered intraperitoneally at doses of 20 and 25 mg/kg, respectively, 5 hours after STZ injection for 21 consecutive days. TAD and BG conceivably attenuated STZ-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the Morris water maze and object recognition tests paralleled by reduced AÝ expression and phosphorylation of tau. Moreover, TAD and BG enhanced the protein expression of pAkt, pGSK-3Ý, beclin-1, and methylated protein phosphatase 2A (PP2A) and cyclin D1 gene expression and raised brain-derived neurotrophic factor immunoreactivity. In addition, both drugs boosted the hippocampal levels of cyclic guanosine monophosphate (cGMP), protein kinase G (PKG), WNT3A, and adenosine monophosphate-activated protein kinase coupled by reduced protein expression of Ý-catenin and mammalian target of rapamycin (mTOR). TAD and BG also halted neuroinflammation as evidenced by reduced IL-23 and IL-27 levels and NF-mB protein expression
530			_aIssued also as CD
653		4	_aBergapten
653		4	_aSporadic Alzheimer{u2019}s disease
653		4	_aTadalafil
700	0		_aNesrine Salah Eldine Elsayed , _eSupervisor
700	0		_aSuzan Mohamed Mansour , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c83935 _d83935