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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.08.03.M.Sc.2021.Ma.A
100 0 _aManar Mohamed Mohamed Elhassan
245 1 0 _aApplication of different analytical techniquesfor the determination of some antidiabetics /
_cManar Mohamed Mohamed Elhassan ; Supervised Maha Abdelmonem Hegazy , Shereen Hassib , Amr Mahmoud Bekhet
246 1 5 _aتطبيق تقنيات تحليلية مختلفة لتعيين بعض الأدوية المضادة لداء السكرى
260 _aCairo :
_bManar Mohamed Mohamed Elhassan ,
_c2021
300 _a232 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry
520 _aThis work is concerned with the determination of some antidiabetic agents of three different classes. Ipragliflozin, Ertugliflozin and Dapagliflozin were selected from the class of Sodium-Glucose cotransporter-II inhibitors. Sitagliptin and Saxagliptin were chosen from the class of dipeptidyl peptidase-IV inhibitors and Metformin was selected from the class of biguanides. The selected drugs have been analyzed using electrochemical, chromatographic and spectrophotometric methods. First, electrochemical methods were employed for the analysis of Ipragliflozin and Sitagliptin. Ipragliflozin was determined using differential pulse voltammetry that depends on the oxidation of sulfur atom. The method was applied by scanning the potential over range of 0 to 2.8 V by using a scan rate of 10 mV/s versus the reference electrode Ag/Ag+ in non-aqueous medium while using glassy carbon electrode as an indicator electrode.The method was then successfully applied for the analysis of Ipragliflozin in spiked human plasma
530 _aIssued also as CD
653 4 _aDapagliflozin
653 4 _aErtugliflozin
653 4 _aIpragliflozin
700 0 _aAmr Mahmoud Bekhet ,
_eSupervisor
700 0 _aMaha Abdelmonem Hegazy ,
_eSupervisor
700 0 _aShereen Hassib ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c83978
_d83978