000			03131cam a2200349 a 4500
003			EG-GiCUC
005			20250223032920.0
008			220215s2021 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2021.Sa.E
100	0		_aSabry Mohamed Ali Ewais
245	1	0	_aEvaluation of the efficacy and Safety of ketogenic diet in children with refractory epilepsy / _cSabry Mohamed Ali Ewais ; Supervised Hanna Mohamed Aboulghar, Nour Mohamed Mohsen Elkhateeb
246	1	5	_aتقييم فاعلية و درجة أمان نظام الحمية الكيتونية الغذائى فى الأطفال المصابين بالصرع المستعصى
260			_aCairo : _bSabry Mohamed Ali Ewais , _c2021
300			_a119 P . : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Although many children with epilepsy will have seizures controlled with antiepileptic drugs (AEDs), a large percentage of patients are refractory to drug therapy and may consider initiating a ketogenic diet (KD). The term Ketogenic Diet Therapy (KDT) refers to any diet therapy in which dietary composition results in a state of ketosis. Objectives: In this study we assessed the ef{uFB01}cacy, safety and tolerability of the KD in children with refractory epilepsy. Outcome predictive values of various clinical factors were also assessed. Methods: This is a prospective study of 40 children with refractory epilepsy, treated with KD at the clinical nutrition clinic of Cairo University Children Hospital between October 2018 and July 2019, and had continuous follow-up at 2, 4 and 6 months. The non-fasting protocol was followed without hospital admission. The classic KD with a ratio 2:1 or 3:1 (grams of fat to combined carbohydrate and protein) was used Results: The median age for the enrolled patients was 43.5 months (range, 5{u2013}137 months). Seizure frequency was assessed at 2, 4 and 6 months after KD initiation for 19, 3 and 18 patients respectively at the time of their last follow up visit. Nineteen (47.5%) patients achieved <50% seizure reduction (including 12 (30%) patients who became seizure free). Three (7.5%) patients achieved > 50% seizure reduction. Seizures increased in 4 (10%) patients while remained unchanged in 14 (35%) patients. Favorable treatment outcome was associated with longer duration on the KD (p-value< 0.001), grams of fat intake (p-value=0.020) and generalized slow background in pre-diet EEG findings (p-value=0.026). Frequently reported adverse effects included gastrointestinal disturbance, hyperlipidemia and food refusal
530			_aIssued also as CD
650		0	_aSafety
653		4	_aEfficacy
653		4	_aKetogenic diet
653		4	_aSeizures
700	0		_aHanna Mohamed Aboulghar , _eSupervising
700	0		_aNour Mohamed Mohsen Elkhateeb , _eSupervising
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c84236 _d84236