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003			EG-GiCUC
005			20260516114337.0
008			220306s2021 ua dh frm 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng _beng _bara
049			_aDeposit
082	0	4	_a540
092			_a540 _221
097			_aPh.D
099			_aCai01.12.02.Ph.D.2021.Ma.E.
100	0		_aMahmod Morad Ragab Mohammed, _epreparation.
245	1	0	_aExpression and polymorphism of long non-coding RNAs in colorectal cancer / _cMahmod Morad Ragab Mohammed ; Supervised Prof.Dr. Ismail Abdelshafy Abdelhamid , Prof.Dr.Heba Mohammed Kamal Abdelhakeem , Prof.Dr.Olfat Gamil Shaker.
246	1	5	_aالتعبير والتباين الجينى للأحماض النووية الريبوزية الطويبة غير المشفرة فى سرطان القولون والمستقيم
264		0	_c2021
300			_a84 Pages : _bcharts , facsimiles ; _c25cm+ _eCD
336			_atext _2rda content
337			_aUnmediated _2rdamedia
338			_avolume _2rdacarrier
502			_aThesis ( Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry
504			_aBibliography: pages 115-137.
520		3	_aBackground: Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors. Diet, smoking and drinking habits are among environmental factors frequently associated with CRC risk. Aim of work:The present study aims to conduct a clinical biochemical study that aids in the investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, Plasmacytoma Variant Translocation-1 (PVT-1) and miR-186 in an attempt to provide new noninvasive diagnostic biomarkers for CRC of the Egyptian patients. Patients and methods: Eighty CRC studies and thirty healthy controls were included. Laboratory and pathological investigations were assessed. Serum miR-186 and long non-coding PVT-1 was measured as well as genotype for PVT-1 rs13255292. Results: The CRC patients had a mean age of 50.91±12.0. The mean serum miR-186 level in CRC patients (1.38±0.21) was significantly higher than in the control (0.93±0.1) (p=0.0001). The PVT-1 level in CRC patients was (5.91±0.25) significantly higher than control (1.1±0.2) (p=0.001). The PVT-1/ rs13255292 genotype CT was significantly higher compared to the control group. The T allele was highly significant with a p-value of 0.008 in the CRC patient group with respect to the control. Conclusion: miR-186, long noncoding PVT-1 as well as PVT-1 the T allele may be considered as genetic markers for CRC susceptibility
530			_aIssued also as CD
546			_aText in English and abstract in Arabic & English.
650		0	_aBiochemistry
653			_aColorectal Cancer (CRC) _aLong non-coding RNAs (lncRNAs) _aMicroRNAs (miRNAs)
700	0		_aHeba Mohammed Kamal Abdelhakeem _ethesis advisor.
700	0		_aIsmail Abd Elshafy Abd Elhamid _ethesis advisor.
700	0		_aOlfat Gamil Shaker _ethesis advisor.
900			_b01-01-2022 _cIsmail Abdelshafy Abdelhamid _cHeba Mohammed Kamal Abdelhakeem _cOlfat Gamil Shaker _UCairo University _FFaculty of Science _DDepartment of Biochemistry
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c84414